841-46-3

Basic information

• Product Name: Phosphoric acid, ethyl diphenyl ester
• CAS NO: 841-46-3
• Molecular Formula: C14H15O4P
• Molecular Weight: 278.244
• Mol File: 841-46-3.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Phosphoric acid, ethyl diphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid, ethyl diphenyl ester(841-46-3)
• EPA Substance Registry System: Phosphoric acid, ethyl diphenyl ester(841-46-3)

Safety Data

• Hazardous Substances Data: 841-46-3(Hazardous Substances Data)

Usage

General Description

Phosphoric acid, ethyl diphenyl ester, also known as diphenyl ethyl phosphate, is a chemical compound that is commonly used as a plasticizer in the production of various types of plastics and synthetic rubbers. It is known for its ability to improve the flexibility and durability of these materials. Additionally, it is utilized as a flame retardant in certain applications, such as in the manufacturing of electrical wires and cables, due to its high resistance to heat and its ability to reduce the risk of fire. However, it is important to handle this compound with care, as it can be harmful if ingested or inhaled and may cause irritation to the skin and eyes if it comes into direct contact.

Upstream product

• 64-17-5 ethanol 
• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 838-85-7 diphenyl hydrogen phosphate 
• 108-95-2 phenol 
• 26386-88-9 diphenyl phosphoryl azide 
• 4712-55-4 diphenyl hydrogen phosphite 
• 10359-36-1 4-nitro-phenyl diphenyl phosphate 
• 502765-18-6 C₁₅H₁₅O₆P 
• 70677-19-9 diphenyl phosphorobromidate 
• 115-86-6 phosphoric acid triphenyl ester 
• 29833-83-8 triphenyl phosphite ozonide 
• 6921-14-8 Diphenyl potassium phosphate 
• 141-52-6 sodium ethanolate 
• 139-02-6 sodium phenoxide 

Downstream Products

• 1150095-29-6 DCCP 
• 91-01-0 1,1-Diphenylmethanol 
• 93-54-9 1-Phenyl-1-propanol 
• 99706-39-5 ethyl bis(2-hydroxyphenyl)phosphinate 
• 25723-74-4 diphenyl(trimethylsilyl)phosphate 
• 2510-86-3 O,O-diethyl O-phenyl phosphate 

Relevant articles and documents

Zinc-catalyzed transformation of diarylphosphoryl azides to diarylphosphate esters and amides

We have developed a facile and efficient procedure for the synthesis of diarylphosphate esters and amides. Using Zn(acac)2 as the catalyst, the reaction of diarylphosphoryl azides with aliphatic alcohols and phenols through an unusual P?N bond cleavage provided a number of diarylphosphate esters in good yields (22 examples, up to 94%). Additionally, various diarylphosphate amides were obtained from the corresponding amines in excellent yields as well (8 examples, up to 96%).

Copper catalyzed synthesis of aryl/alkyl mixed phosphates from diphenylphosphoryl azides and aliphatic alcohols under mild conditions

An efficient and convenient one-pot protocol is developed to prepare aryl/alkyl mixed phosphates in the presence of copper catalyst under exceptionally mild conditions. A series of versatile, ubiquitous, and inexpensive phosphoryl azides and aliphatic alcohols are combined for the first time ever. Diphenylphosphoryl azide is employed as novel phosphors reagent through an unexpected cleavage of P[sbnd]N bond. The transformation is advantageous with respect to a broad of functional group compatibility and different esterification products are isolated in good to excellent results. This new catalytic system represents a superior platform towards a mild, operationally simple, practical, and scalability alternative to access target molecules. Furthermore, a plausible mechanism is proposed based on insightful mechanistic studies.

Reactive intermediates in the H-phosphonate synthesis of oligonucleotides

The formation of H-phosphonate diesters is an important step in the synthesis of oligonucleotides. Using diphenylchlorophosphate as the activator for the coupling step is often accompanied by side reactions as a result of self 'capping' and other reactions of the reactive intermediate. In the absence of base, the activation of ethyl H-phosphonate with diphenylchlorophosphate probably occurs through the intermediate formation of bis diethyl pyro-di-H-phosphonate rather than the expected diphenyl ethyl pyro-H-phosphonate. Pyridine acts as a nucleophilic catalyst converting diphenylchlorophosphate to its pyridinium adduct. Several side and unwanted reactions are quantified so that conditions to minimise these can be identified.