842-79-5

Basic information

• Product Name: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole;methyl 4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl ether;2-Phenyl-5-(4-methoxyphenyl)-1,3,4-oxadiazole
• CAS NO: 842-79-5
• Molecular Formula: C₁₅H₁₂N₂O₂
• Molecular Weight: 252.26798
• EINECS: 212-675-0
• Mol File: 842-79-5.mol
• Article Data: 68

Chemical Properties

• Boiling Point: 413.3°C at 760 mmHg
• Flash Point: 203.8°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole(842-79-5)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole(842-79-5)

Safety Data

• Hazardous Substances Data: 842-79-5(Hazardous Substances Data)

Usage

General Description

2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole is a chemical compound that belongs to the oxadiazole family. It is a heterocyclic compound containing one oxygen and two nitrogen atoms in its five-membered ring structure. 2-(4-methoxyphenyl)-5-phenyl-1,3,4-oxadiazole has potential applications in various fields, including pharmaceuticals, agrochemicals, and material science. It has shown promising biological activities, such as antimicrobial, anticancer, and anti-inflammatory properties. Additionally, it is used in the development of organic electronic materials due to its unique electronic and optical properties. Its diverse range of applications make it a valuable compound in the field of chemical research and development.

InChI:InChI=1/C15H12N2O2/c1-18-13-9-7-12(8-10-13)15-17-16-14(19-15)11-5-3-2-4-6-11/h2-10H,1H3

Upstream product

• 6781-59-5 1-benzoyl-2-(4-methoxybenzoyl)hydrazine 
• 23133-34-8 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole 
• 77-78-1 dimethyl sulfate 
• 41980-89-6 4-methoxy-benzoic acid N'-thiobenzoyl-hydrazide 
• 59635-52-8 N-(phenylsulfonyl)benzohydrazonoyl chloride 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 98-88-4 benzoyl chloride 
• 6926-51-8 5-(4-methoxyphenyl)-2H-tetrazole 
• 60413-24-3 2,5-bis-(4-methoxy-phenyl)-3-methyl-[1,3,4]oxadiazolium; toluene-4-sulfonate 
• 613-94-5 benzoic acid hydrazide 
• 51651-81-1 4-methoxy-benzoic acid benzylidenehydrazide 
• 6926-51-8 5-(4-methoxyphenyl)-1H-tetrazole 
• 93-97-0 benzoic acid anhydride 
• 14850-86-3 N'-(4-methoxybenzylidene)benzohydrazide 

Downstream Products

• 1239666-98-8 11-[4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-phenoxy]-undecan-1-ol 
• 1239666-99-9 C₂₉H₃₆N₂O₄ 
• 335276-14-7 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-bis(bromomethyl)benzene 
• 335276-13-6 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-dimethyl benzene 
• 173865-05-9 2-methyl-acrylic acid 4-(5-phenyl-[1,3,4]oxadiazol-2-yl)phenyl ester 
• 1456-67-3 2-(4'-methoxyphenyl)-5-phenyl-1,3,4-thiadiazole 
• 23133-34-8 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)

Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.

Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions

1,3,4-Oxadiazoles are a kind of useful heterocycles which can be frequently found in materials and bioactive molecules. In this study, intermolecular electrochemical cyclization between α-keto acids and acylhydrazines has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles with the yield up to 91 %. This transformation can be run under mild reaction conditions in the absence of external oxidant, base and transition metal catalyst. Both symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles could be prepared according to the careful choice of the substrate combination. Gram scale synthesis also illustrates the potential application of this protocol in large preparation.

Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

[Figure not available: see fulltext.] A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.