6781-59-5

Basic information

• Product Name: N-benzoyl-4-methoxy-benzohydrazide
• CAS NO: 6781-59-5
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.288
• Mol File: 6781-59-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 531°Cat760mmHg
• Flash Point: 274.9°C
• Density: 1.217g/cm³
• CAS DataBase Reference: N-benzoyl-4-methoxy-benzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-4-methoxy-benzohydrazide(6781-59-5)
• EPA Substance Registry System: N-benzoyl-4-methoxy-benzohydrazide(6781-59-5)

Safety Data

• Hazardous Substances Data: 6781-59-5(Hazardous Substances Data)

Upstream product

• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 613-94-5 benzoic acid hydrazide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 
• 201230-82-2 carbon monoxide 
• 65-85-0 benzoic acid 
• 100-09-4 4-methoxybenzoic acid 
• 121-98-2 methyl 4-methoxybenzoate 
• 98-88-4 benzoyl chloride 
• 198974-12-8 2-[2-(4-chlorophenyl)-2-oxoethylidene]-5-phenylfuran-3(2H)-one 

Downstream Products

• 1156534-56-3 2-(4-methoxyphenyl)-5-phenyl-1,3,4-selenadiazole 
• 1214913-31-1 2-[4-(5-phenyl-1,3,4-thiadiazole-2-yl)-phenoxy] ethanol 
• 1214913-30-0 4-(5-phenyl-1,3,4-thiadiazole-2-yl) phenol 
• 4156-04-1 2-(4-methoxyphenyl)-5-phenyl-1H-1,3,4-triazole 
• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 335276-14-7 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-bis(bromomethyl)benzene 
• 335276-13-6 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-dimethyl benzene 
• 23133-34-8 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole 
• 471910-31-3 3-(4-methoxyphenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 4156-04-1 3-(4-methoxyphenyl)-5-phenyl-1H-1,2,4-triazole 
• 91099-00-2 2'-(4-methoxybenzyl)benzohydrazide 
• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 1239666-98-8 11-[4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-phenoxy]-undecan-1-ol 
• 1239666-99-9 C₂₉H₃₆N₂O₄ 

Relevant articles and documents

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.

One-Pot Catalytic Approach for the Selective Aerobic Synthesis of Imines from Alcohols and Amines Using Efficient Arene Diruthenium(II) Catalysts under Mild Conditions

A green and efficient catalytic approach for the selective synthesis of imines in air at room temperature was achieved with the aid of newly synthesised diruthenium(II) complexes [(η6-p-cymene)2Ru2Cl2(μ-L)] containing substituted 1,2-diacylhydrazine ligands. All the new complexes were fully characterised by analytical and spectroscopic techniques. The solid-state structure of a representative complex was solved by single-crystal X-ray diffraction analysis. The diruthenium(II) complexes also enable the selective aerobic oxidation of alcohols to aldehydes. The catalytic reaction operates in the presence of air as a green and cheap oxidant, and releases water as the only by-product. A plausible mechanism is proposed for the imine formation, which is believed to proceed via an aldehyde intermediate.

Stability or flexibility: Metal nanoparticles supported over cross-linked functional polymers as catalytic active sites for hydrogenation and carbonylation

A novel cross-linked functional polymer was prepared through copolymerization between 1, 3, 4, 6-tetraallylglycoluril and 4-vinyl pyridine. Pt and Pd nanoparticles supported over this polymeric framework (Pt/CFP and Pd/CFP) were detailedly characterized by TEM, EDS, and XPS. Pt nanoparticles were kept in the monodispersed state with the average size of 1.4 nm. Monodispersed Pd nanoparticles were about 4.5 nm. The hydrogenation of nitrobenzenes over Pt/CFP shows high activity and selectivity with the substrate to Pt ratio of 4000 under mild reactions. Pd/CFP was the catalyst for carbonylation of aryl iodides in the presence of secondary amines and acylhydrazines. Double carbonylation with secondary amines produced α-ketoamides with the selectivity of 80%. Diacylhydrazine molecules were synthesized by the direct carbonylation of aryl iodide with acylhydrazine over Pd/CFP. The recyclability and recoverability of Pt/CFP were investigated through a seven-run recycling test of nitrobenzene hydrogenation. The flexibility of Pd/CFP in the carbonylation process was thoroughly explored by a 12-run recycling test. Supported Pt or Pd nanoparticles showed the macroscopic robustness in their catalytic performance in the catalytic cycle. The flexibility of metal nanoparticles and the polymeric supports guaranteed macroscopic catalytic robustness.