6781-59-5

Upstream product

• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 613-94-5 benzoic acid hydrazide 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 65-85-0 benzoic acid 
• 100-09-4 4-methoxybenzoic acid 
• 121-98-2 methyl 4-methoxybenzoate 
• 198974-12-8 2-[2-(4-chlorophenyl)-2-oxoethylidene]-5-phenylfuran-3(2H)-one 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 1456-67-3 2-(4'-methoxyphenyl)-5-phenyl-1,3,4-thiadiazole 
• 1239666-99-9 C₂₉H₃₆N₂O₄ 
• 1239666-98-8 11-[4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-phenoxy]-undecan-1-ol 
• 1214913-31-1 2-[4-(5-phenyl-1,3,4-thiadiazole-2-yl)-phenoxy] ethanol 
• 1214913-30-0 4-(5-phenyl-1,3,4-thiadiazole-2-yl) phenol 
• 4156-04-1 2-(4-methoxyphenyl)-5-phenyl-1H-1,3,4-triazole 
• 1156534-56-3 2-(4-methoxyphenyl)-5-phenyl-1,3,4-selenadiazole 
• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 335276-14-7 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-bis(bromomethyl)benzene 
• 335276-13-6 2-(10'-(p-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)decanoxy)-1,4-dimethyl benzene 
• 23133-34-8 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole 
• 471910-31-3 3-(4-methoxyphenyl)-4-methyl-5-phenyl-4H-1,2,4-triazole 
• 4156-04-1 3-(4-methoxyphenyl)-5-phenyl-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.

Preparation method and application of multifunctional ultraviolet absorbent

The invention relates to a preparation method and application of a multifunctional ultraviolet absorbent for terylene. The general structural formula of the absorbent is as follows: formula, wherein Y is a quaternary ammonium salt group. According to the preparation method and application of the multifunctional ultraviolet absorbent for terylene disclosed by the invention, the dyeing mode of the ultraviolet absorbent to terylene is similar to disperse dyes, and fabrics can be subjected to anti-ultraviolet finishing by using a high-temperature and high-pressure exhausting method and can also be dyed with the disperse dyes in the same bath; the finished fabrics not only have good anti-ultraviolet properties, but also have the effects of killing or inhibiting Gram-positive bacteria and Gram-negative bacteria represented by staphylococcus aureus and Escherichia coli; and meanwhile, the fabrics have good anti-static function.

One-Pot Catalytic Approach for the Selective Aerobic Synthesis of Imines from Alcohols and Amines Using Efficient Arene Diruthenium(II) Catalysts under Mild Conditions

A green and efficient catalytic approach for the selective synthesis of imines in air at room temperature was achieved with the aid of newly synthesised diruthenium(II) complexes [(η6-p-cymene)2Ru2Cl2(μ-L)] containing substituted 1,2-diacylhydrazine ligands. All the new complexes were fully characterised by analytical and spectroscopic techniques. The solid-state structure of a representative complex was solved by single-crystal X-ray diffraction analysis. The diruthenium(II) complexes also enable the selective aerobic oxidation of alcohols to aldehydes. The catalytic reaction operates in the presence of air as a green and cheap oxidant, and releases water as the only by-product. A plausible mechanism is proposed for the imine formation, which is believed to proceed via an aldehyde intermediate.

Stability or flexibility: Metal nanoparticles supported over cross-linked functional polymers as catalytic active sites for hydrogenation and carbonylation

A novel cross-linked functional polymer was prepared through copolymerization between 1, 3, 4, 6-tetraallylglycoluril and 4-vinyl pyridine. Pt and Pd nanoparticles supported over this polymeric framework (Pt/CFP and Pd/CFP) were detailedly characterized by TEM, EDS, and XPS. Pt nanoparticles were kept in the monodispersed state with the average size of 1.4 nm. Monodispersed Pd nanoparticles were about 4.5 nm. The hydrogenation of nitrobenzenes over Pt/CFP shows high activity and selectivity with the substrate to Pt ratio of 4000 under mild reactions. Pd/CFP was the catalyst for carbonylation of aryl iodides in the presence of secondary amines and acylhydrazines. Double carbonylation with secondary amines produced α-ketoamides with the selectivity of 80%. Diacylhydrazine molecules were synthesized by the direct carbonylation of aryl iodide with acylhydrazine over Pd/CFP. The recyclability and recoverability of Pt/CFP were investigated through a seven-run recycling test of nitrobenzene hydrogenation. The flexibility of Pd/CFP in the carbonylation process was thoroughly explored by a 12-run recycling test. Supported Pt or Pd nanoparticles showed the macroscopic robustness in their catalytic performance in the catalytic cycle. The flexibility of metal nanoparticles and the polymeric supports guaranteed macroscopic catalytic robustness.

In situ generated cetyltrimethylammonium bisulphate in choline chloride-urea deep eutectic solvent: A novel catalytic system for one pot synthesis of 1,3,4-oxadiazole

Cetyltrimethylammonium bisulphate ([CTA]HSO4) catalysed one pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles from carboxylic acid and acid hydrazide in biodegradable deep eutectic solvent is investigated. [CTA]HSO 4 is generated in situ from cetyltrimethylammonium peroxodisulphate. Cyclization of diacylhydrazide using [CTA]HSO4 gives best alternative to traditional dehydration agents. Its remarkable features include a milder procedure, simplicity in workup and purification, good to excellent yields of products, use of inexpensive, recyclable reagents, and eco-friendly aspects by avoiding toxic catalysts/reagents and solvents. Graphical Abstract: [Figure not available: see fulltext.].

17O NMR studies of substituted 1,3,4-oxadiazoles

Three series of substituted 1,3,4-oxadiazoles were studied by 17O NMR spectroscopy. Chemical shifts values were correlated with empirical Hammett parameters as well as calculated bond lengths and chemical shielding values.

The synthesis, electrochemical and fluorescent properties of monomers and polymers containing 2,5-diphenyl-1,3,4-thiadiazole

Three, 2,5-diphenyl-1,3,4-thiadiazole-containing vinyl monomers and their polymers were synthesized and the HOMO and LUMO energies of the compounds, as estimated from cyclic voltammetry data, were -6.35 to -6.14 eV and -3.02 to -2.84 eV, respectively. The optical band gaps (Eg) were similar to those determined from cyclic voltammograms. The fluorescent emission spectra of all monomers and polymers displayed either blue or green light emission.

Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles

A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted- 1,3,4-oxadiazoles in good to very good yields.

The spectrophotometric study of a fluorescence-enhanced inclusion complex Threaded with β-cyclodextrin: Synthesis and characterization

A novel achiral monomer end-capped with a phenyl-[1,3,4]oxadiazolyl group and threaded through β-cyclodextrin was synthesized to investigate the host-guest interactions in the inclusion complex. 1H NMR studies revealed that one or two eyclodextrin molecules were threaded onto the synthesized achiral monomer, leading to the formation of a fibrous construction of self-assembled inclusion complexes. The formation of a self-assembled inclusion complex was identified using SEM and TEM. The highly ordered alignment of selfassembled supramolecules was confirmed using polarized optical microscopy. We demonstrate an easy process for the fabrication of nano-structured self-assembled inclusion complexes in pyridine/ethanol (1 mL/10 mL) as well as the enhancement of photo-induced fluorescence via monomers end-capped with a phenyl-[1,3,4]oxadiazolyl moiety threaded with β-cyclodextrins.

Facile synthesis and stracture of novel 2,5-disubstituted 1,3,4-selenadiazoles

The reaction of hydrazide with carbony] chloride in the presence of sodium carbonates leads to the corresponding 1,2- diacylhydrazines [1a-t, R 1C(O)NHNHC(O)R2, R1 = aryl, R2 = aryl or alkyl] in moderate to excellent yield (57-90%). The latter reacts with 2,4-diphenyl-l,3-diselenadiphosphetane- 2,4-diselenide (Woollins' reagent, WR) in refluxing toluene to give a series of new 2,5-disubstituted 1,3,4-selenadiazoles (2a-t, 51-99% yield). All compounds were characterized spectroscopically and six compounds were characterized crystalloqraphically. Wiley-VCH Verlag GmbH & Co. KGaA.