842169-79-3

Upstream product

• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 4039-32-1 lithium hexamethyldisilazane 

Downstream Products

• 778565-93-8 (R)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine 
• 336105-43-2 (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine hydrochloride 
• 842169-80-6 1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine 

Relevant academic research and scientific papers

Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives

Unprotected β-(het)aryl-β-fluoroalkyl β-amino acids and their α-hydroxy derivatives can be readily obtained using a decarboxylative Mannich-type reaction without protection/deprotection steps. This protocol utilizes lithium hexamethyldisilazide and (het)arylfluoroalkyl ketones to generate NH-ketimine intermediates. The mild reaction conditions allow the preparation of original fluorinated β-amino acids as useful building blocks in a practical and scalable manner.

REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B

The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B and/or monoamine oxidase-A, and therefore useful to treat or prevent neurological diseases or conditions in mammals, preferably humans.