84218-71-3Relevant articles and documents
Anti-coagulation pentasaccharide and preparing method and medical application thereof
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, (2019/01/23)
The invention relates to a synthesized pentasaccharide compound, salt thereof, and application of the pentasaccharide compound in preparing medicines for preventing and/or treating blood coagulation disorder related diseases.
Anti-coagulation pentasaccharide compound and preparing method and medical application thereof
-
, (2019/01/23)
The invention relates to an anti-coagulation medicine, in particular to a synthesized pentasaccharide compound, salt thereof, and a preparing method and medical application of the pentasaccharide compound. The pentasaccharide compound or acid or salt thereof in the ion form shown in the formula II (the formula can be seen in the description) is synthesized and has stronger anti-coagulation factorXa activity and a longer elimination half life compared with sodium sulfonate. The pentasaccharide compound can be used for preparing medicines for preventing and treating blood coagulation disorder related diseases such as deep venous thrombosis, thrombophlebitis, artery blockage caused by thrombosis or embolism and postoperative vein thrombosis or embolism.
A Mild and Environmentally Benign Synthetic Protocol for Catalytic Hydrolysis of Thioglycosides
Barua, Pankaj M. Bujar,Sahu, Priti Rani,Mondal, Ejabul,Bose, Gopal,Khan, Abu T.
, p. 81 - 84 (2007/10/03)
A wide variety of thioglycosides 1 are selectively hydrolyzed to the corresponding 1-hydroxy sugars 2 in good yields at 0-5 deg C, by employing V2O5-H2O2 catalyzed oxidation of ammonium bromide in CH2Cl2-H2O solvent system. The methodology is very mild, environmentally benign, efficient and highly chemoselective. No side reactions such as bromination either at the anomeric position or double bond or oxidation at the sulfur are encountered.