84218-71-3Relevant academic research and scientific papers
Anti-coagulation pentasaccharide and preparing method and medical application thereof
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, (2019/01/23)
The invention relates to a synthesized pentasaccharide compound, salt thereof, and application of the pentasaccharide compound in preparing medicines for preventing and/or treating blood coagulation disorder related diseases.
Anti-coagulation pentasaccharide and preparing method and medical application thereof
-
Paragraph 0105; 0111, (2019/01/23)
The invention relates to an anti-coagulation medicine, in particular to a synthesized pentasaccharide compound, salt thereof, and a preparing method and medical application of the pentasaccharide compound. The pentasaccharide compound or acid or salt thereof in the ion form shown in the formula III (the formula can be seen in the description) is synthesized and has stronger anti-coagulation factorXa activity and a longer elimination half life compared with sodium sulfonate. The pentasaccharide compound can be used for preparing medicines for preventing and treating blood coagulation disorderrelated diseases such as deep venous thrombosis, thrombophlebitis, artery blockage caused by thrombosis or embolism and postoperative vein thrombosis or embolism.
Anti-coagulation pentasaccharide compound and preparing method and medical application thereof
-
, (2019/01/23)
The invention relates to an anti-coagulation medicine, in particular to a synthesized pentasaccharide compound, salt thereof, and a preparing method and medical application of the pentasaccharide compound. The pentasaccharide compound or acid or salt thereof in the ion form shown in the formula II (the formula can be seen in the description) is synthesized and has stronger anti-coagulation factorXa activity and a longer elimination half life compared with sodium sulfonate. The pentasaccharide compound can be used for preparing medicines for preventing and treating blood coagulation disorder related diseases such as deep venous thrombosis, thrombophlebitis, artery blockage caused by thrombosis or embolism and postoperative vein thrombosis or embolism.
A useful and convenient synthetic procedure for hydrolysis of thioglycosides
Mondal, Ejabul,Bujar Barua, Pankaj M.,Bose, Gopal,Khan, Abu T.
, p. 210 - 211 (2007/10/03)
Various thioglycosides 1 are smoothly hydrolyzed chemo-selectively to the corresponding 1-hydroxy sugars 2 in good yields at 0-5°C by employing (NH4)6Mo7O24· 4H2O-H2O2 or H2MoO4·H2O-H2O2 to promote oxidation of ammonium bromide in the presence of perchloric acid in CH2Cl2-H2O solvent system. Mild conditions, good yields, no side reactions such as bromination either at the anomeric position or double bond, and even oxidation at the sulfur are some of the major advantages.
A Mild and Environmentally Benign Synthetic Protocol for Catalytic Hydrolysis of Thioglycosides
Barua, Pankaj M. Bujar,Sahu, Priti Rani,Mondal, Ejabul,Bose, Gopal,Khan, Abu T.
, p. 81 - 84 (2007/10/03)
A wide variety of thioglycosides 1 are selectively hydrolyzed to the corresponding 1-hydroxy sugars 2 in good yields at 0-5 deg C, by employing V2O5-H2O2 catalyzed oxidation of ammonium bromide in CH2Cl2-H2O solvent system. The methodology is very mild, environmentally benign, efficient and highly chemoselective. No side reactions such as bromination either at the anomeric position or double bond or oxidation at the sulfur are encountered.
Chemical synthesis of 6'''-α-maltotriosyl-maltohexaose as substrate for enzymes in starch biosynthesis and degradation
Damager, Iben,Erik Olsen, Carl,Lindberg Moller, Birger,Saddik Motawia, Mohammed
, p. 19 - 30 (2007/10/03)
A branched nonasaccharide 6'''-α-maltotriosyl-maltohexaose was synthesised in 40 steps from D-glucose and maltose. Phenyl O-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1→4)-O-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-(1→4)-2,3-di-O-benzyl-1-thio-β-D-glucop
109. Oligosaccharide analogues of polysaccharides: Part 8. Orthogonally protected cellobiose-derived dialkynes. A convenient method for the regioselective bromo- and protodegermylation of trimethylgermyl- and trimethylsilyl-protected dialkynes
Ernst, Alexander,Vasella, Andrea
, p. 1279 - 1294 (2007/10/03)
The cellobiose-derived dialkynes 14 and 15 were prepared by glycosidation of the acceptor 9 with the thioglycosides 12 (82%) and 13 (85%), respectively. The acceptor 9 was prepared from the known alcohol 2 via the lactone 7 in five steps (48% overall), an
Stereoselective total synthesis of wheat flour ceramide dihexoside.
Koike,Mori,Ito,Nakahara,Ogawa
, p. 2931 - 2939 (2007/10/02)
A plant glycosphingolipid, O-(beta-D-mannopyranosyl)-(1----4)-O-(beta-D-glucopyranosyl)-(1----1)-(2 S,3S,4R)-4-hydroxy-N-tetracosanoylsphinganine 1, and the stereoisomer, O-(alpha-D-mannopyranosyl)-(1----4)-O-(beta-d-glucopyranosyl)-(1----1)-( 2S,3S,4R)-4
Synthetic Studies on Rhynchosporoside and Related Substances
Sugawara, Fumio,Nakayama, Haruhiko,Strobel, Gary A.,Ogawa, Tomoya
, p. 2251 - 2260 (2007/10/02)
The stereoselective synthesis of the 1-O-α-D-glucopyranosides and 1-O-α-D-cellobiosides of 3-deoxy-2(R)- and 2(S)-glycerols to determine the complete stereochemistry of rhynchosporoside, which is a host selective phytotoxin from Rhynchosporium secalis, is
