84586-45-8Relevant academic research and scientific papers
NH4I-mediated sp3 C-H cross-dehydrogenative coupling of benzylamines with 2-methylquinoline for the synthesis of E-2-styrylquinolines
Huang, Bin,Li, Xue,Liao, WeiBo,Wang, JiangWei,Zhang, YuanYuan
, p. 903 - 910 (2021/07/17)
Without any metal catalyst, a simple and efficient method for the synthesis of E-2-styrylquinolines through sp3 C-H cross-dehydrogenative coupling of benzylamines with 2-methylquinolines mediated by NH4I under air is successfully developed. The oxidative olefination proceeded through deamination and sp3 C–H bond activation. A plausible mechanism is proposed for the construction of E-2-styrylquinolines.
Metal-free oxidative olefination of primary amines with benzylic C-H bonds through direct deamination and C-H bond activation
Gong, Liang,Xing, Li-Juan,Xu, Tong,Zhu, Xue-Ping,Zhou, Wen,Kang, Ning,Wang, Bin
supporting information, p. 6557 - 6560 (2014/08/18)
An oxidative olefination reaction between aliphatic primary amines and benzylic sp3 C-H bonds has been achieved using N-bromosuccinimide as catalyst and tert-butyl hydroperoxide as oxidant. The olefination proceeds under mild metal-free conditions through direct deamination and benzylic C-H bond activation, and provides easy access to biologically active 2-styrylquinolines with (E)-configuration. This journal is the Partner Organisations 2014.
Studies on Pyrimidine Derivatives. XXXVI. Reaction of 6-Substituted 2,4-Dimethylpyrimidines with Benzaldehyde in the Presence of Zinc Chloride
Sakamoto, Takao,Yoshizawa, Hiroshi,Yamanaka, Hiroshi
, p. 2005 - 2010 (2007/10/02)
The condensation of 2,4(2,6)-dimethylpyrimidines (7a-c), but not 6-methoxy-2,4-dimethylpyrimidine (7d), with benzaldehyde in the presence of zinc chloride occurred at the 4(6)-methyl group predominantly.In contrast, the reaction of 7d under the same condi
Studies on Pyrimidine Derivatives. XXX. The Palladium-Catalyzed Cross-Coupling Reaction of Iodopyrimidines with Terminal Olefinic Compounds
Sakamoto, Takao,Arakida, Hiroko,Edo, Kiyoto,Yamanaka, Hiroshi
, p. 3647 - 3656 (2007/10/02)
The influence of triphenylphosphine, used as a ligand, on the palladium-catalyzed cross-coupling reaction of iodopyrimidines with olefins such as ethyl acrylate, acrylonitrile, and styrene was investigated.In general, the addition of triphenylphosphine was concluded to retard the reaction in the pyrimidine series.The effect of triphenylphosphine in the monoazine series is also discussed.Keywords - palladium catalyst; carbon-carbon bond formation; homo-coupling reaction of N-heteroaromatic iodide; raction conditions; six-membered N-heteroaromatic iodide; substituted ethenylpyrimidine
