84645-64-7Relevant academic research and scientific papers
Computer-Assisted Selective Optimization of Side-Activities—from Cinalukast to a PPARα Modulator
Pollinger, Julius,Schierle, Simone,Neumann, Sebastian,Ohrndorf, Julia,Kaiser, Astrid,Merk, Daniel
supporting information, p. 1343 - 1348 (2019/07/04)
Automated computational analogue design and scoring can speed up hit-to-lead optimization and appears particularly promising in selective optimization of side-activities (SOSA) where possible analogue diversity is confined. Probing this concept, we employ
[2+2] Photodimerization of (E)-styrylthiazoles through cation-π-controlled preorientation
Yamada, Shinji,Yamagami, Kaoru,Oaku, Saki
, p. 2451 - 2454 (2016/05/19)
Cation-π-controlled preorientation of (E)-styrylthiazoles was performed in both solution and solid phases. Irradiation of (E)-styrylthiazoles in the presence of HCl produced synHT dimers in good selectivities, while little selectivity was observed without
Palladium-catalyzed c-2 selective olefination of thiazoles
Liu, Wei,Yu, Xin,Kuang, Chunxiang
supporting information, p. 1798 - 1801 (2014/04/17)
A highly efficient protocol for C2 selective alkenylation of electron-deficient thiazoles is developed. High C2 position selectivity for alkenylation products is achieved at a neutral environment, and a possible pathway of oxidative alkenylation is discussed. This methodology provides a simple way to construct a 2-alkenyl-thiazole moiety.
Suzuki-Miyaura cross-coupling reactions of potassium alkenyltrifluoroborates
Molander, Gary A.,Bernardi, Carmem R.
, p. 8424 - 8429 (2007/10/03)
We have previously reported that the palladium-catalyzed cross-coupling reaction of air-stable potassium alkenyltrifluoroborates with aryl halides and triflates proceeds readily with good yields. Recent progress in outlining the scope and limitations of s
Diheteroarylmethanes. 5. E-Z isomerism of carbanions substituted by 1,3-Azoles: 13C and 15N π-charge/shift relationships as source for mapping charge and ranking the electron-withdrawing power of heterocycles
Abbotto, Alessandro,Bradamante, Silvia,Pagani, Giorgio A.
, p. 1761 - 1769 (2007/10/03)
Previously proposed π-charge/shift relationships have been applied to 13C and 15N shifts of the carbanions of 2-benzylazoles (thiazole, oxazole, and imidazole), their corresponding benzo-fused analogs, and bis(2-azolyl)methanes (azol
THIAZOLYLMETHYLENETRIPHENYLPHOSPHORANE AND ITS BENZO DERIVATIVE: STABLE AND PRACTICAL WITTIG REAGENTS FOR THE SYNTHESIS OF VINYLTHIAZOLES AND VINYLBENZOTHIAZOLES. TWO-CARBON HOMOLOGATION OF ALDEHYDES.
Dondoni, Alessandro,Fantin, Giancarlo,Fogagnolo, Marco,Medici, Alessandro,Pedrini, Paola
, p. 2021 - 2032 (2007/10/02)
The title thiazolyl phosphorane is a stable yet quite reactive Wittig-type reagent which uppon reaction with various aldehydes affords vinylthiazoles, mainly or exclusively as E-isomers, in very good yields.Also the benzothiazolyl phosphorane derivative, unlike a literature report, prove to react with aldehydes.Vinylthyazoles subjected to formyl deblocking from thiazole nucleous afford two-carbon homologated satured aldehydes.As an example, one of these vinylthiazoles, viz. the β-phenyl derivative 8f, proves to add n-butyl lithium cuprate to give after the formyl deblocking 3-phenylheptanal.
