847899-98-3Relevant academic research and scientific papers
Lewis acid assisted ring-closing metathesis of chiral diallylamines: An efficient approach to enantiopure pyrrolidine derivatives
Yang, Qian,Xiao, Wen-Jing,Yu, Zhengkun
, p. 871 - 874 (2005)
(Chemical Equation Presented) Lewis acid assisted ring-closing olefin metathesis (RCM) of chiral diallylamines, using the second generation RCM ruthenium-based catalyst, leads to enantiopure pyrrolidine derivatives in 79-93% yields under very mild conditi
De novo design and synthesis of a γ-turn peptidomimetic scaffold and its application as JNK3 allosteric ligand
Kim, Mi-Hyun,Lee, Junghun,Hah, Jung-Mi
, p. 1318 - 1326 (2015)
As a way to develop a neuroprotective agent for the JNK3-JIP1-binding site, peptidomimetics of JIP-1 as JNK3 allosteric regulators have been examined. The study consisted of in silico scaffold hopping, molecular docking, solution and solid-phase peptide s
Pauson-Khand reaction of amino acid derived 3-pyrrolines: New enantiopure scaffolds for diversity-oriented synthesis
Cuevas, Félix,García-Granda, Carmen,Buschmann, Helmut,Torrens, Antoni,Yenes, Susana,Pericàs, Miquel A.
, p. 119 - 122 (2008/03/13)
Amino acid derived 3-pyrrolines can be readily prepared in a single step in enantiomerically pure form by cycloalkylation of the corresponding amino esters with (Z)-1,4-dichloro-2-butene. Enantiopure azabicyclo[3.3.0]octenones can be then easily obtained
Microwave-assisted ring-closing metathesis of diallylamines: a rapid synthesis of pyrrole and pyrroline derivatives
Yang, Qian,Li, Xin-Yong,Wu, Hong,Xiao, Wen-Jing
, p. 3893 - 3896 (2007/10/03)
The ring-closing metathesis (RCM) reactions of diallylamines occurred under controlled microwave irradiation. In addition to the high reaction rate, the key features of the reaction are that it can be carried out without deactivation of the substrates and
