848749-72-4Relevant academic research and scientific papers
Synthesis of indolo[2,1-: A] isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions
Wei, Yun-Long,Chen, Jian-Qiang,Sun, Bo,Xu, Peng-Fei
supporting information, p. 5922 - 5925 (2019/05/27)
We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a]isoquinoline derivatives bearing various functional groups were synthesized using this method in good to excellent yields.
Base-promoted domino reaction for the synthesis of 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes
Wu, Yan-Dong,Ma, Jun-Rui,Shu, Wen-Ming,Zheng, Kai-Lu,Wu, An-Xin
, p. 4821 - 4826 (2016/07/18)
A base-promoted domino reaction to synthesize the 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes has been developed. This strategy provides a simple and beneficial way for the construction of 2,3-disubstituted indole compounds from readily available starting materials under mild conditions.
Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group
Muralirajan, Krishnamoorthy,Cheng, Chien-Hong
, p. 1571 - 1576 (2014/06/09)
A regioselective synthesis of indoles from arylhydrazine hydrochlorides with alkynes and diethyl ketone catalyzed by a rhodium complex is described. A possible mechanism involving an in-situ generated oxidizing directing group -N-Ni'CR1R2 assisted ortho-C-H activation and reductive elimination are proposed. The catalytic reaction is highly compatible with a wide range of functional arylhydrazines and alkynes. The reaction proceeds under mild reaction conditions and is atom-step economical.
Oxidative cleavage reaction of substituted indoles catalyzed by plant cell cultures
Takemoto, Masumi,Iwakiri, Yasutaka,Tanaka, Kiyoshi
, p. 373 - 383 (2008/03/12)
We have developed a novel method for the oxidative cleavage of indole carbon double bonds in the presence of H2O2 using plant cell cultures as peroxidase. The oxidative method has some advantage, as features such as mild reactions, good yields, easy work-up and safety.
Substituted phenyl indoles
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Page/Page column 15, (2008/06/13)
The present invention relates generally to substituted phenyl indoles and methods of using them.
Derivatives of 5-amidine indole as inhibitors of thrombin catalytic activity
Iwanowicz, Edwin J.,Lau, Wan F.,Lin, James,Roberts, Daniel G. M.,Seiler, Steven M.
, p. 1339 - 1344 (2007/10/03)
Substituted 5-amidine indoles were constructed based upon a computational analysis of putative modes of binding to thrombin utilizing coordinates from the crystal structure of BMS-183,507-α-thrombin complex. These analogs display competitive kinetics for
