84940-51-2

Basic information

• Product Name: Pyridine, 4-(difluoromethyl)-2-fluoro- (9CI)
• Synonyms: Pyridine, 4-(difluoromethyl)-2-fluoro- (9CI)
• CAS NO: 84940-51-2
• Molecular Formula: C6H4F3N
• Molecular Weight: 147.0978696
• Product Categories: HALIDE
• Mol File: 84940-51-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 4-(difluoromethyl)-2-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(difluoromethyl)-2-fluoro- (9CI)(84940-51-2)
• EPA Substance Registry System: Pyridine, 4-(difluoromethyl)-2-fluoro- (9CI)(84940-51-2)

Safety Data

• Hazardous Substances Data: 84940-51-2(Hazardous Substances Data)

Upstream product

• 108-89-4 picoline 
• 1511-62-2 bromodifluoromethane 
• 128071-98-7 4-bromo-2-fluoropyridine 
• 131747-60-9 (2-fluoropyridin-4-yl)methanol 
• 131747-69-8 2-fluoropyridin-4-carboxyaldehyde 

Relevant articles and documents

D-AMINO ACID OXIDASE ACTIVITY INHIBITING COMPOUNDS

Compounds of formula (I), wherein R1 through R3 are as defined in the claims, or pharmaceutically acceptable esters, salts, hydrates or solvates thereof, useful as DAAO inhibitors as well as pharmaceutical compositions containing the

Metallaphotoredox Difluoromethylation of Aryl Bromides

Herein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl-radical-mediated halogen abstraction. The merger of this fluoroalkyl electrophile activation pathway with a dual nickel/photoredox catalytic platform enables the difluoromethylation of a diverse array of aryl and heteroaryl bromides under mild conditions. The utility of this procedure is showcased in the late-stage functionalization of several drug analogues.

8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)

FLUORINATIONS WITH COMPLEX METAL FLUORIDES. PART 7. FLUORINATIONS OF THE METHYL PYRIDINES WITH CAESIUM TETRAFLUOROCOBALTATE

4-Methylpyridine passed over caesium tetrafluorocobaltate at 330-340 deg gave tridecafluoro(1,3-dimethylpyrrolidine) (1) and its 3-difluoromethyl analogue (2), together with a range of polyfluoro-4-picolines (4-10) with -CF3, -CHF2 or -CH2F groups in the 4-position. 3-Methylpyridine similarly gave 1 and its 1,2-isomer (11) together with several polyfluoro-3-picolines (14-18). 2-Methylpyridine at 270 deg gave tridecafluoro(1-ethylpyrrolidine) (13), a trace of 11 and 2-trifluoromethyl- (22), 2-difluoromethyl- (23) and 2-fluoromethyl-tetrafluoropyridine (24); there were also products arising by loss of methyl.Other unidentified fluoroalkylpyridines besides those isolated were present in each case.