849669-49-4

Upstream product

• 849669-48-3 (1S,2R,4aS,8aS)-1-[(5-Ethyl-2,3-dimethoxy-phenyl)-hydroxy-methyl]-2,5,5,8a-tetramethyl-decahydro-naphthalen-2-ol 
• 103476-92-2 (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furan-2-ol 
• 86546-84-1 (5S,8R,10S)-drim-9⁽¹¹⁾-en-8-ol 
• 1376654-31-7 (1R,2R,4aS,8aS)-1-(iodoethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-yl formate 
• 849669-41-6 1-bromo-2,3-dimethoxy-5-ethylbenzene 
• 1376654-39-5 borono-sclareolide 
• 52617-99-9 (+)-drimane-8,11-diol 
• 564-20-5 (3aR)-(+)-sclareolide 
• 5293-42-5 1-bromo-2,3-dimethoxy-5-ethenyl benzene 
• 52618-00-5 (1R,2R,4aS,8aS)-(+)-2-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydro-2,5,5,8a-tetramethyl-naphthalen-1-aldehyde 

Relevant academic research and scientific papers

Synthesis of pelorol and its analogs and their inhibitory effects on phosphatidylinositol 3-kinase

There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper, the synthesis of pelorol has been completed, and the synthesis of some intermediates has been optimized and scaled up. Five pelorol analogs have also been prepared. Preliminary biological activity testing demonstrated that compounds 5 and 6 might be potential lead compounds for cancer therapy.

Scalable, divergent synthesis of meroterpenoids via "borono- sclareolide"

A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of "borono- sclareolide", a terpenyl radical precursor that enables gram-scale preparation of (+)-chromazonarol. Subsequent synthetic operations on this key intermediate permit rapid access to a variety of related meroterpenoids, many of which possess important biological activity.

Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP

(Chemical Equation Presented) A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analog