849831-52-3

Upstream product

• 946088-70-6 C₂₂H₂₅BrN₂O₂ 

Downstream Products

• 894791-74-3 (S)-1-(3-(2-Aminopropan-2-yl)phenyl)propan-2-amine 
• 1057253-65-2 (S)-benzyl 1-(3-(2-azidopropan-2-yl)phenyl)propan-2-ylcarbamate 
• 1057253-68-5 (S)-benzyl 1-(3-(2-hydroxypropan-2-yl)phenyl)propan-2-ylcarbamate 
• 946088-61-5 C₃₁H₃₁N₂O₃P 
• 946088-74-0 C₁₉H₂₂N₂O₃ 
• 913722-72-2 benzyl (S)-1-(3-((S)-1-N-Boc-aminoethyl)phenyl)propan-2-ylcarbamate 
• 1057086-30-2 benzyl (S)-1-(3-((S)-1-aminoethyl)phenyl)propan-2-ylcarbamate 
• 881207-02-9 Benzyl (S)-1-(3-((R)-1-aminoethyl)phenyl)propan-2-ylcarbamate 
• 1057086-31-3 benzyl (S)-1-(3-((S)-1-azidoethyl)phenyl)propan-2-ylcarbamate 
• 946088-73-9 Benzyl (S)-1-(3-((R)-1-hydroxyethyl)phenyl)propan-2-ylcarbamate 
• 946088-72-8 C₁₉H₂₃NO₃ 
• 881206-91-3 (S)-benzyl 1-(3-acetylphenyl)propan-2-ylcarbamate 
• 872059-44-4 [2-(3-bromo-phenyl)-1S-methyl-ethyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Comparative approaches toward diamines containing spatially separated homobenzylic and benzylic nitrogen stereocenters

Several synthetic strategies to diamines 1-3 are described. The optimum approach via opening of aziridine afforded 1-3 in 29-60% yield over 3-5 steps. A study on formation of the benzylic stereocenter using Toste's rhenium-catalyzed asymmetric reduction of phosphinyl ketimines was also evaluated and afforded 15 in 92% de.

Asymmetric hydrogenation of α,β-unsaturated carboxylic acids catalyzed by ruthenium(II) complexes of spirobifluorene diphosphine (SFDP) ligands

The ruthenium diacetate complexes ligated by chiral spirobifluorene diphosphines (SFDP) were very effective catalysts for the asymmetric hydrogenation of tiglic acid derivatives and α-methylcinnamic acid derivatives with high activities and excellent enantioselectivities (up to 98% ee). The α-aryloxybutenoic acids can also be hydrogenated by these catalysts to provide the corresponding saturated α-aryloxybutanoic acids in high yields (89-93%) and enantioselectivities (up to 95% ee). In this reaction, the SFDP ligand with para-methyl groups on the P-phenyl rings gave the best results.

Highly rigid diphosphane ligands with a large dihedral angle based on a chiral spirobifluorene backbone

High and wide: The high rigidity and large dihedral angle of chiral, spirobifluorene-based diphosphane ligands lead to excellent reactivity and enantioselectivity in the ruthenium-catalyzed asymmetric hydrogenation of α,β-unsaturated carboxylic acids (see scheme).