894791-74-3

Upstream product

• 1057253-65-2 (S)-benzyl 1-(3-(2-azidopropan-2-yl)phenyl)propan-2-ylcarbamate 
• 39172-32-2 2-(3-bromophenyl)-2-methyl-[1,3]dioxolane 
• 107484-93-5 C₁₀H₁₁BrMgO₂ 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 25108-58-1 1-bromo-3-isopropenylbenzene 
• 946088-69-3 C₉H₉BrMg 
• 946088-67-1 C₂₀H₂₁NO₂ 
• 946088-66-0 C₁₈H₁₆F₃NO₅S 
• 946088-65-9 C₁₁H₁₀F₃NO₅S 
• 1057253-68-5 (S)-benzyl 1-(3-(2-hydroxypropan-2-yl)phenyl)propan-2-ylcarbamate 
• 881206-91-3 (S)-benzyl 1-(3-acetylphenyl)propan-2-ylcarbamate 
• 872059-44-4 [2-(3-bromo-phenyl)-1S-methyl-ethyl]-carbamic acid benzyl ester 
• 849831-52-3 3-(3-bromophenyl)-2-methylpropionic acid 
• 30951-66-7 2-(3-bromophenyl)-2-propanol 

Relevant academic research and scientific papers

Comparative approaches toward diamines containing spatially separated homobenzylic and benzylic nitrogen stereocenters

Several synthetic strategies to diamines 1-3 are described. The optimum approach via opening of aziridine afforded 1-3 in 29-60% yield over 3-5 steps. A study on formation of the benzylic stereocenter using Toste's rhenium-catalyzed asymmetric reduction of phosphinyl ketimines was also evaluated and afforded 15 in 92% de.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present invention relates to pyridines, pyrimidines and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic beta cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.