851179-99-2

Upstream product

• 524959-64-6 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetonitrile 
• 107367-98-6 2-(5-Methyl-2-phenyl-4-oxazolyl)-acetic acid 
• 103788-65-4 (5-methyl-2-phenyloxazol-4-yl)ethanol 
• 103788-61-0 (5-methyl-2-phenyl-4-oxazolyl)methyl chloride 
• 105-45-3 acetoacetic acid methyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 
• 100-52-7 benzaldehyde 
• 27492-46-2 4,5-dimethyl-2-phenyl-oxazole 3-oxide 
• 157284-85-0 methyl 2-(4-hydroxybenzyl)-3-oxobutanoate 
• 157284-83-8 2-acetyl-3-(4-hydroxy-phenyl)-acrylic acid methyl ester 
• 851180-88-6 3-methyloxyimino-2-(4-hydroxy-benzyl)-butyric acid methyl ester 
• 227029-27-8 2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate 

Relevant academic research and scientific papers

Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists

Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13 nM in PPARα and γ, respectively. It showed better g

NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARγ) and alpha (PPARα), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.