851784-80-0

Basic information

• Product Name: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate
• Synonyms: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate
• CAS NO: 851784-80-0
• Molecular Weight: 360.237
• Mol File: 851784-80-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate(851784-80-0)
• EPA Substance Registry System: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate(851784-80-0)

Safety Data

• Hazardous Substances Data: 851784-80-0(Hazardous Substances Data)

Usage

General Description

2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate is a chemical compound with the molecular formula C19H21Cl2NO4. It is a diester derivative of isoquinoline containing a tert-butyl group, a methyl group, and two chlorine atoms. 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate has potential pharmaceutical applications due to its structural properties and potential biological activities. It may be used in the development of new drugs with therapeutic effects, including antiviral, antibacterial, antifungal, and anticancer properties. Additionally, it could be utilized in medicinal chemistry research and drug discovery processes. Overall, 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate is a significant compound with potential pharmacological significance and biomedical applications.

Upstream product

• 67-56-1 methanol 
• 851784-78-6 C₁₅H₁₆Cl₂F₃NO₅S 
• 201230-82-2 carbon monoxide 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 851784-76-4 tert-butyl 5,7-dichloro-6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1609545-55-2 C₉H₉Cl₂NO*C₇H₈O₃S 
• 14446-24-3 6-hydroxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 1194550-65-6 benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate hydrochloride 
• 1194550-67-8 ((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 
• 851784-82-2 2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 

Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF LIFITEGRAST

The present invention relates to a novel process for the preparation of lifitegrast of Formula (I). The present invention further provides a novel process for the purification of lifitegrast of Formula (I).

Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists

This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1. In addition to excellent in vitro potency, 6q shows good pharmacokinetic properties and its ethyl ester (6t) demonstrates good oral bioavailability in both mouse and rat. Either intravenous administration of 6q or oral administration of its ethyl ester (6t) produced a significant reduction of neutrophil migration in a thioglycollate-induced murine peritonitis model.