852615-10-2

Basic information

• Product Name: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(3,4-dimethoxy-benzyl)-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione
• Synonyms: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(3,4-dimethoxy-benzyl)-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione
• CAS NO: 852615-10-2
• Molecular Weight: 1134.62
• Mol File: 852615-10-2.mol

Chemical Properties

• CAS DataBase Reference: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(3,4-dimethoxy-benzyl)-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(3,4-dimethoxy-benzyl)-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione(852615-10-2)
• EPA Substance Registry System: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(3,4-dimethoxy-benzyl)-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione(852615-10-2)

Safety Data

• Hazardous Substances Data: 852615-10-2(Hazardous Substances Data)

Upstream product

• 852615-07-7 3-(3,4-dimethoxybenzyl)-4-(3-hydroxypropenyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-1,3-dihydro-imidazol-2-one 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 345642-39-9 (S)-1-(Toluene-4-sulfonyl)-5-triisopropylsilanyloxymethyl-1,5-dihydro-pyrrol-2-one 
• 98-79-3 L-Pyroglutamic acid 
• 222307-13-3 (S)-(+)-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one 
• 4931-66-2 methyl (S)-pyroglutamate 
• 17342-08-4 (S)-Pyroglutaminol 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 91950-62-8 methanesulfonic acid 2-(toluene-4-sulfonyl)-ethyl ester 
• 15645-75-7 1,1’-[(Z)-ethene-1,2-diyldisulfonyl]bis(4-methylbenzene) 
• 22381-54-0 2-(p-tolylsulfonyl)ethanol 
• 13154-24-0 triisopropylsilyl chloride 
• 896141-51-8 (S)-1-(Toluene-4-sulfonyl)-5-triisopropylsilanyloxymethyl-pyrrolidin-2-one 
• 852615-26-0 3-{3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazol-4-yl}-acrylic acid ethyl ester 

Downstream Products

• 852615-11-3 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(3,4-dimethoxy-benzyl)-8b-hydroxy-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,3,5,5a,7,8,8a,8b-octahydro-imidazo[4,5-e]isoindole-2,6-dione 

Relevant articles and documents

A unified synthetic strategy toward oroidin-derived alkaloids premised on a biosynthetic proposal

Details of the evolution of a synthetic strategy toward the spirocyclic chlorocyclopentane core of oroidin-derived alkaloids, including the axinellamines and potentially adaptable to palau'amine, are described. A proposed refinement of the Kinnel-Scheuer biosynthetic proposal for palau'amine is posited. Studies undertaken to improve the regioselectivity and efficiency of a key Diels-Alder reaction utilizing a novel protecting group strategy, microwave chemistry, and other strategies are described. Further insights regarding the suitability of different protecting groups during the epoxidation/chlorination/ring contraction sequence are disclosed. Several interesting by-products from this reaction sequence are reported. These studies have led to a unified synthetic strategy to the axinellamines and palau'amine.

Highly regioselective diels-alder reactions toward oroidin alkaloids: Use of a tosylvinyl moiety as a nitrogen masking group with adjustable electronics

(Chemical Equation Presented) The use of the p-toluenesulfonyl (Ts) and tosylvinyl (Tsv) groups as nitrogen masking groups imparted high regioselectivity in Diels-Alder reactions directed toward members of the oroidin-derived marine alkaloid family. The e