85292-39-3

Upstream product

• 342002-85-1 methyl 4-((2-benzoylhydrazono)methyl)benzoate 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 1203709-73-2 (4-methoxyformylphenyl)(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate 
• 613-94-5 benzoic acid hydrazide 
• 1571-08-0 methyl 4-formylbenzoate 
• 66395-10-6 4-(N'-Benzoyl-hydrazinocarbonyl)-benzoic acid methyl ester 
• 82544-82-9 5-tetrazole 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1191034-17-9 1-(9-ethyl-9H-carbazol-3-yl)-3-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]propane-1,3-dione 
• 85292-45-1 4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzoic acid 

Relevant academic research and scientific papers

Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents

To discover antifungal compounds with broad-spectrum and stable metabolism, a series of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives was designed and synthesized. Compounds A30-A34 exhibited excellent broad-spectrum antifungal activity against Candida albicans with MIC values in the range of 0.03–0.5 μg/mL, and against Cryptococcus neoformans and Aspergillus fumigatus with MIC values in the range of 0.25–2 μg/mL. In addition, compounds A31 and A33 showed high metabolic stability in human liver microsomes in vitro, with the half-life of 80.5 min and 69.4 min, respectively. Moreover, compounds A31 and A33 showed weak or almost no inhibitory effect on the CYP3A4 and CYP2D6. The pharmacokinetic evaluation in SD rats showed that compound A31 had suitable pharmacokinetic properties and was worthy of further study.

C-H arylation of azaheterocycles: A direct ligand-free and Cu-catalyzed approach using diaryliodonium salts

An efficient and high yielding Cu-catalyzed direct C-H arylation of azaheterocycles including oxadiazoles, thiadiazoles, benzoxazoles and benzothiazoles has been achieved by employing easily accessible diaryliodonium salts. the Partner Organisations 2014.

Cu(II) catalyzed imine C-H functionalization leading to synthesis of 2,5-substituted 1,3,4-oxadiazoles

A direct access to symmetrical and unsymmetrical 2,5-disubstituted [1,3,4]-oxadiazoles has been accomplished through an imine C-H functionalization of N-arylidenearoylhydrazide using a catalytic quantity of Cu(OTf)2. This is the first example of amidic oxygen functioning as a nucleophile in a Cu-catalyzed oxidative coupling of an imine C-H bond. These reactions can be performed in air atmosphere and moisture making it exceptionally practical for application in organic synthesis.

Synthesis of a novel β-diketone containing carbazole and 2,5-diphenyl-1,3,4-oxadiazole fragments

A novel β-diketone containing carbazole and 2,5-diphenyl-1,3,4- oxadiazole fragments as hole- and electron-transporting functional groups, respectively, was synthesized via efficient and convenient procedure. The product attracts interest from the viewpoint of its potential applications as optoelectronic material.

Microwave assisted syntheses of 2,5-disubstituted 1,3,4-oxadiazoles

2,5-Di-substituted 1,3,4-oxadiazoles have been synthesized from the oxidation of 1-aroyl-2-arylidene hydrazines with potassium permanganate on the surface of solid mineral support as well as in the mixture of acetone and water under microwave irradiation. 2,5-Disubstituted 1,3,4-oxadiazoles have been synthesized by oxidation of 1-aroyl-2-arylidene hydrazines with potassium permanganate on the surface of a solid mineral support as well as in mixtures of acetone and water under microwave irradiation.

FUNCTION REGULATOR FOR RETINOID RELATIVE RECEPTOR

The present invention provides a retinoid-related receptor (except retinoic acid receptors) function regulatin agent comprising a compound represented by the formula: wherein one of R1 and R2 is an optionally substituted monocyclic a

Research in the 2,5-Diaryl-1,3,4-oxadiazole Series. 1. Electronic Structures and Spectral-Luminescence Properties of Substituted 2,5-Diphenyl-1,3,4-oxadiazoles

The dependence of the spectral-luminescence properties of substituted 2,5-diphenyl-1,3,4-oxadiazoles on the electronic nature of the substituents was studied.Experimental and theoretical studies confirm the electron-acceptor character of the oxadiazole ring and constitute evidence for the rather effective transmission of the electronic effects through the heteroring.