85354-34-3Relevant academic research and scientific papers
The absolute configuration of 2-bromo-2,3-dihydro-1H-inden-1-ols
Prysiazhnuk, Dmitry V.,Rusanov, Eduard B.,Kolodiazhnyi, Oleg I.
supporting information, p. 3023 - 3031 (2021/08/13)
All four possible stereoisomers of cis- and trans-2-bromo-2,3-dihydro-1H-inden-1-ols, which are important intermediates in the synthesis of biologically active compounds, were synthesized and their configurations were studied by enzymatic kinetic resoluti
A useful propionate cofactor enhancing activity for organic solvent-tolerant recombinant metal-free bromoperoxidase (perhydrolase) from Streptomyces aureofaciens
China, Hideyasu,Ogino, Hiroyasu
, p. 327 - 332 (2019/07/12)
The oxidative brominating activity of an organic solvent-tolerant recombinant metal-free bromoperoxidase BPO-A1 with C-terminal His-tag (rBPO-A1), from Streptomyces aureofaciens found to depend on various additives. These included carboxylic acids, used as cofactors and alcohols, used as water-miscible organic solvents. Enzyme activity was significantly enhanced by using propanoic acid (PA) as a cofactor, which had a high Log D at pH 5.0 and ethylene glycol with a low Log P. The positional specificity of oxidative hydroxybromination for olefins, using rBPO-A1 and PA in the presence of methanol, was higher compared to a non-enzymatic reaction using peracetic acid. The oxidative bromination step, occurring after enzymatic peroxidation step, is suggested to be pseudoenzymatic.
Lipase-mediated resolution of indene bromohydrin
Igarashi, Yoshio,Otsutomo, Shinya,Harada, Masayuki,Nakano, Shigeru,Watanabe, Shoji
, p. 549 - 552 (2007/10/03)
Lipase-mediated resolution of indene bromohydrin was examined, and we have found that immobilized CAL (Candida antarctica lipase SP525 immobilized on acurrell) was an efficient biocatalyst to resolve a readily available racemic indene bromohydrin (+)-1. Enantiomerically enriched (1R,2R)-2- bromoindan-1-ol (-)-1 and its (1S,2S)-acetate (+)-2 were obtained by this method.
