85356-37-2

Upstream product

• 85356-31-6 (2S*,3R*)-3-Amino-2-methyl-1-phenyl-3-p-tolyl-1-propanone 
• 75-36-5 acetyl chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 93-55-0 1-phenyl-propan-1-one 
• 75-05-8 acetonitrile 
• 85356-26-9 [3-Imino-2-methyl-1-phenyl-3-p-tolyl-prop-(Z)-ylidene]-p-tolyl-amine 
• 55619-31-3 Cyclohexyl-[3-imino-2-methyl-1-phenyl-3-p-tolyl-prop-(Z)-ylidene]-amine 

Downstream Products

• 97275-79-1 (1R,2R,3S)-3-Ethylamino-2-methyl-1-phenyl-3-p-tolyl-propan-1-ol 
• 97211-00-2 (1S,2R,3S)-3-Ethylamino-2-methyl-1-phenyl-3-p-tolyl-propan-1-ol 

Relevant academic research and scientific papers

ZrOCl2·8H2O: an efficient Lewis acid catalyst for the one-pot multicomponent synthesis of β-acetamido ketones

Aromatic aldehydes were reacted in one-pot with enolisable ketones, acetonitrile and acetyl chloride at ambient temperature in the presence of ZrOCl2·8H2O to furnish the corresponding β-acetamido ketones in very good to excellent yie

Iodine as an efficient catalyst for one-pot multicomponent synthesis of β-acetamido ketones

Iodine efficiently catalyzes the three-component coupling of aromatic aldehydes, enolizable ketones or keto esters, and acetonitrile in the presence of acetyl chloride to afford β-acetamido ketones in good yields at room temperature. Georg Thieme Verlag S

Studying catalytic activity of ternary mixed-metal Keggin H7SiV3W9O40 as a versatile acid catalyst for the synthesis of β-acetamido ketones

One-pot four-component condensation of an aromatic aldehyde with an enolisable ketone and acetyl chloride is investigated in the presence of H7SiV3W9O40 in acetonitrile. The prepared catalyst was characterized by standard techniques such as XRD, SEM, and FT-IR to verify the Keggin structure of nanocatalyst. Furthermore, findings revealed a very good catalytic activity for the applied vanadium substituted heteropolyacid in this acid catalyzed condensation reaction. A series of Keggin Si and V-substituted heteropolyacids were compared for the synthesis of β-acetamido-β-(4-chlorophenyl)propiophenone, which showed a better catalytic activity for H7SiV3W9O40 and H4SiW12O40 than the lacunary and mixed metal Keggin H4SiW9Mo3O40 and H5SiW9Mo2VO40. In addition, effect of the nitrilating agent was also demonstrated in this catalytic system and findings show less proficiency for PhCN compared to acetonitrile. Moreover, propiophenone as an α-substituted enolisable ketone was reacted with some aromatic aldehydes and the anti isomer is detected as the major diastereomer. Therefore, H7SiV3W9O40 can be introduced as a new effective, inexpensive, and eco-friendly catalyst for the introduced four-component condensation reaction.

Supported L-pyrrolidine-2-carboxylic acid-4-hydrogen sulphate on silica gel as an economical and efficient catalyst for the one-pot preparation of ?-acetamido ketones via a four-component condensation reaction

An efficient, one-pot, four-component condensation of aldehydes, acetophenone (or propiophenone), acetyl chloride and acetonitrile in the presence of catalytic amounts of L-pyrrolidine-2-carboxylic acid-4-hydrogen sulphate (supported on silica gel), a gre

Supported L-pyrrolidine-2-carboxylic acid-4-hydrogen sulphate on silica gel as an economical and efficient catalyst for the one-pot preparation of for the one-pot preparation of β-acetamido ketones via a four-component condensation reaction

An efficient, one-pot, four-component condensation of aldehydes, acetophenone (or propiophenone), acetyl chloride and acetonitrile in the presence of catalytic amounts of L-pyrrolidine-2-carboxylic acid-4-hydrogen sulphate (supported on silica gel), a gre

Efficient one-pot synthesis of β-acetamido carbonyl compounds using Fe3O4 nanoparticles

A new, one-pot condensation of aldehydes, enolizable ketones and esters, AcCl, and MeCN, in the presence of Fe3O4 nanoparticles (nano-Fe3O4) as an efficient catalyst, for the preparation of β-acetamido carbonyl compounds at room temperature is described. Copyright

Reduction of 1,3-Diimines. A New and General Method of Synthesis of γ-Diamines, β-Amino Ketones, and Derivatives with Two and Three Chiral Centers

1,3-Diimes 1 are easily reduced with Na/i-PrOH to afford unsymmetrical N-substituted γ-diamines 8 in nearly quantitative yields.Since three chiral centers are generated, compounds 8 are isolated as a mixture of diastereoisomers which are easily separated.