85620-43-5

Upstream product

• 99686-39-2 (E)-2-bromo-3-phenylprop-2-enal 
• 41109-94-8 5t-phenyl-2-cyano-pentadien-(2ξ.4)-oic acid-(1)-methyl ester 
• 60-29-7 diethyl ether 
• 109-89-7 diethylamine 
• 14371-10-9 (E)-3-phenylpropenal 
• 105-34-0 methyl 2-cyanoacetate 
• 104-55-2 3-phenyl-propenal 
• 57194-69-1 cinnamaldehyde 

Downstream Products

• 41109-94-8 5c-phenyl-2-cyano-pentadien-(2ξ.4)-oic acid-(1)-methyl ester 
• 113966-56-6 (2R,3S)-2-Cyano-3-((Z)-styryl)-oxirane-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

One-Pot Synthesis of γ-Azidobutyronitriles and Their Intramolecular Cycloadditions

Efficient gram-scale, one-pot approaches to azidocyanobutyrates and their amidated or decarboxylated derivatives have been developed, starting from commercially available aldehydes and cyanoacetates. These techniques combine (1) Knoevenagel condensation,

Lipase-catalyzed Knoevenagel condensation between α,β- unsaturated aldehydes and active methylene compounds

A simple and efficient Knoevenagel condensation between α,β-unsaturated aldehydes and active methylene compounds is reported. Notably, this condensation can be catalyzed by PPL (lipase from porcine pancreas) with satisfied yields (49%-92%). Moreover, PPL induces moderate Z/E selectivity in the Knoevenagel condensation.

Novel, efficient, and green procedure for the Knoevenagel condensation catalyzed by diammonium hydrogen phosphate in water

Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds such as methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammo

Novel, efficient, and green procedure for the Knoevenagel condensation catalyzed by diammonium hydrogen phosphate in water

Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammoniu

Natural phosphate doped with potassium fluoride and modified with sodium nitrate: Efficient catalysts for the Knoevenagel condensation

A high yield synthesis of activated alkenes is described using the inexpensive natural phosphate alone, doped with potassium fluoride or modified by sodium nitrate. The Knoevenagel condensation was carried out in mild conditions at room temperature in met

Fluorapatite/sodium nitrate as a solid support for the Knoevenagel reaction

The Knoevenagel reaction is assisted by sodium nitrate/fluorapatite in heterogeneous media. The reaction is carried out between an activated methylene and an aldehyde at room temperature without a solvent. The yields obtained are very high.

Ammonium acetate-basic alumina catalyzed knoevenagel condensation under microwave irradiation under solvent-free condition

Ammonium acetate and basic alumina catalyzed efficiently the Knoevenagel condensation of aldehydes and ketones with active methylene compounds under solvent-free condition where olefinic products were obtained in high yields.

KNOEVENAGEL CONDENSATION CATALYSED BY ALUMINIUM OXIDE.

The Knoevenagel condensation of carbonyl compounds with active methylene compounds was readily carried out with aluminium oxide as catalyst.