861449-92-5

Upstream product

• 67-56-1 methanol 
• 64-67-5 diethyl sulfate 
• 33251-20-6 1,4-diphenylbutane-1,2,4-trione 
• 103456-98-0 cis-1,4-diphenyl-2-methoxy-2-butene-1,4-dione 
• 77-78-1 dimethyl sulfate 
• 7647-01-0 hydrogenchloride 
• 33073-99-3 cis-1,4-diphenyl-2-ethoxy-2-butene-1,4-dione 
• 24298-68-8 4,4-dimethoxy-1,4-diphenyl-butane-1,3-dione 
• 7664-93-9 sulfuric acid 
• 108-24-7 acetic anhydride 
• 181511-08-0 3-butoxy-2,5-diphenylfuran 
• 32147-16-3 meso-2,3-dibromo-1,4-diphenyl-1,4-butanedione 
• 1087-09-8 1,4-diphenyl-but-2-yne-1,4-dione 
• 536-74-3 phenylacetylene 

Downstream Products

• 25244-42-2 3,4-dichloro-2,5-diphenyl-furan 

Relevant academic research and scientific papers

A alkynyl dione compound and its synthesis method

The invention discloses a synthetic method of an alkynyl diketone compound which is shown in a formula (II). The synthetic method comprises the following step: in methylbenzene, at 90 DEG C, carrying out a reaction to obtain the alkynyl diketone compound by using alpha hydroxy-ketone and terminal alkyne as reaction raw materials and oxygen as an oxidizing agent under the effect of a copper catalyst. The synthetic method provided by the invention has the advantages that the reaction is efficient and the yield is high; oxygen is used as the oxidizing agent; the reaction condition is mild and no strong acids or strong bases are needed; cheap metals are used for catalyzing; reaction substrates are easy to prepare; amplified reaction can be further achieved.

Oxidative coupling of terminal alkyne with α-hydroxy ketone: An expedient approach toward ynediones

An efficient and mild copper-catalyzed one-pot approach toward ynediones has been established. A variety of ynediones were constructed directly through oxidative coupling of alkyne with α-hydroxy ketone. Oxygen-oxidizing and neutral conditions in one-pot for a wide range of substrates including natural product derivatives make this transformation highly efficient and practical. On the basis of control experiments, in situ IR measurements, and isotopic labeling experiments, a plausible mechanism involving intermediate phenylglyoxal was drawn. Applications by synthesis of various heterocycles were also investigated.

Convenient transformation of 3-alkoxyfurans to 2-alkoxy-3-furanones or cis-2-alkoxy-2-butene-1,4-diones with phenyltrimethylammonium tribromide

3-Alkoxy-2,5-diphenylfurans and 3-alkoxy-2,4,5-triphenylfurans were converted to 2-alkoxy-3-furanones with phenyltrimethylammonium tribromides(PTAB) in various alcohols at room temperature. The oxidative ring-opening of 3-alkoxy-2,5-diphenylfurans to cis-