86310-45-4

Upstream product

• 34887-18-8 diethyl 2,2-diphenethylmalonate 
• 123-51-3 i-Amyl alcohol 
• 103-63-9 1-phenyl-2-bromoethane 
• 105-53-3 diethyl malonate 

Downstream Products

• 17486-92-9 2-(2-phenylethyl)-3,4-dihydro-2H-naphthalen-1-one 
• 62115-21-3 2-phenethyl-4-phenyl-butyric acid amide 
• 855222-57-0 2-phenethyl-4-phenyl-butyric acid-(2-diethylamino-ethyl ester) 
• 855215-89-3 2-phenethyl-4-phenyl-butyryl chloride 
• 145600-21-1 2,2'-bis(2-phenylethyl)-N,N'-bis(8-quinolyl)malonamide 
• 861330-79-2 diphenethyl-malonyl chloride 
• 17486-91-8 2-(2-phenylethyl)-4-phenylbutanoic acid 

Relevant academic research and scientific papers

CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER

The invention provides novel compounds of formula (I), wherein: R1 is a radical derived from one of the known ring systems; R2 is a phenyl radical optionally substituted; Xn represents a birradical selected from the group consisting of: -(CH2)1-4-, (C2-C4)-alkenyl, (C2-C4)alkynyl, -S-(CH2)1-3-#, and -(CH2)1-3-O-#; wherein the symbol # indicates the position at which Xn is attached to R1; Yn is a birradical selected from the group consisting of: -(CH2)2-4-, -S-(CH2)1-3#, and -O-(CH2)1-3-#,; where in the symbol # indicates the position at which Yn is attached to R2; and R3 is a radical selected from the group consisting of: -OR4. The compounds of formula (I) are useful in the treatment of cancer

Role of Substituents in Copper(II) Extraction with N,N'-Bis(8-quinolyl)malonamides

It has been found that substituents on N,N'-bis (8-quinolyl)malonamide play an important role in copper(II) extraction: among the substituents studied, benzyl groups dramatically increased extractability of the malonamide complex.The role of substituents is discussed on the basis of the results of titration and 1H NMR measurements of copper(II) or nickel(II) complexes as well as copper(II)-extraction experiments.Intramolecular interactions between ? electrons of the benzyl group and the metal centre of the complex are proposed to occur.

Dipeptides as renin inhibitors

Dipeptides are described which are represented by the formula STR1 wherein the various substituents are defined hereinbelow. These compounds have a strong inhibitory efect on human renin, and are useful as a therapeutically active agent for the treatment of hypertension, especially renin-associated hypertension.