86317-99-9

Upstream product

• 86317-87-5 N-Hydroxy-N-(4-nitrophenyl)-N'-phenylbenzamidin 
• 98-59-9 p-toluenesulfonyl chloride 
• 86317-86-4 N-Hydroxy-N'-(4-nitrophenyl)-N-phenylbenzamidin 
• 56594-79-7 4-<(4'-nitrophenyl)amino>aniline 
• 100-65-2 N-Phenylhydroxylamine 
• 350-46-9 4-Fluoronitrobenzene 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 100-52-7 benzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 100-00-5 4-chlorobenzonitrile 
• 636-98-6 p-nitrobenzene iodide 
• 38430-03-4 N-phenylbenzimidoyl chloride 
• 34918-79-1 N-(4-nitro-phenyl)-benzimidoyl chloride 
• 98-88-4 benzoyl chloride 

Relevant academic research and scientific papers

Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore

Being the base of several non-communicable diseases, including cancer, inflammation is a complex process generated by tissue damage or change in the body homeostatic state. Currently, the therapeutic treatment for chronic inflammation related diseases is

Involvement of conformational isomerism in the complexity of the crystal network of 1-(4-nitrophenyl)-1H-1,3-benzimidazole derivatives driven by C—H…A (A = NO2, Npy and π) and orthogonal Npy…NO2 and ONO…Csp

A detailed structural analysis of the benzimidazole nitroarenes 1-(4-nitrophenyl)-1H-1,3-benzimidazole, C13H9N3O2, (I), 1-(4-nitrophenyl)-2-phenyl-1H-1,3-benzimidazole, C19H13N3O

A one-pot synthesis of 1, 2 - diaryl benzimidazole and its derivatives

The invention discloses a one-pot synthesis method of 1,2-diarylbenzimidazole and derivatives thereof and belongs to the technical field of chemical preparation. The synthesis method comprises the following steps: adding o-phenylenediamine, benzaldehyde and halogeno benzene which are raw materials into a pressure bottle of 50mL according to the ratio of 1:1.2:1, adding a metal catalyst, an alkali, a ligand and an organic solvent, stirring at the temperature of 110-130 DEG C for 16-24 hours to synthesize 1,2-diarylbenzimidazole and derivatives thereof, cooling, filtering, extracting, distilling at a reduced pressure, and carrying out chromatographic separation by using a column to obtain purified products. The one-pot synthesis method disclosed by the invention has the advantages of mild reaction condition, simple post-treatment, high product selectivity and wide substrate expansion range, and in addition, the one-pot synthesis method can be used for constructing polyaryl imidazole compounds and derivatives easily and efficiently.

Memory Effects and 1,3-Diazepine Ring Closure in Arylnitrenium Ions

15N- and 18O-Labelling experiments demonstrate that in the aromatic rearrangement of N,N'-diphenyl-N-(4-tosyloxy)benzamidines (2 -> 3 - 6) a strong memory effect occurs in oriented contact ion pairs.The formation of 1,3-diazepines 9 by ring closure betwee