864516-83-6Relevant academic research and scientific papers
The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes
Wang, Zhixin,Li, Yang,Chen, Fan,Qian, Peng-Cheng,Cheng, Jiang
, p. 1810 - 1813 (2021/02/27)
In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.
Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties
Petasis, Nicos A.,Keledjian, Raquel,Sun, Yee-Ping,Nagulapalli, Kalyan C.,Tjonahen, Eric,Yang, Rong,Serhan, Charles N.
, p. 1382 - 1387 (2008/09/19)
A new class of chemically and metabolically stable lipoxin analogs featuring a replacement of the tetraene unit of native LXA4 with a substituted benzo-fused ring system have been designed and studied. These molecules were readily synthesized v
Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities
O'Sullivan, Timothy P.,Vallin, Karl S. A.,Shah, Syed Tasadaque Ali,Fakhry, Jér?me,Maderna, Paola,Scannell, Michael,Sampaio, Andre L. F.,Perretti, Mauro,Godson, Catherine,Guiry, Patrick J.
, p. 5894 - 5902 (2008/03/17)
Lipoxins are a group of biologically active eicosanoids typically formed by transcellular lipoxygenase activity. Lipoxin A4 (LXA4) and Lipoxin B4 (LXB4) biosynthesis has been detected in a variety of inflammator
Benzo lipoxin analogues
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Page/Page column 20, (2008/06/13)
Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease a
