86499-39-0

Basic information

• Product Name: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)
• Synonyms: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI);alpha-[(2,3,4,5-Tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]benzenebutanoic acid ethyl ester
• CAS NO: 86499-39-0
• Molecular Formula: C22H26N2O3
• Molecular Weight: 366.45
• Mol File: 86499-39-0.mol

Chemical Properties

• Appearance: /
• Density: 1.17
• CAS DataBase Reference: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)(86499-39-0)
• EPA Substance Registry System: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)(86499-39-0)

Safety Data

• Hazardous Substances Data: 86499-39-0(Hazardous Substances Data)

Usage

Uses

As the specific uses and properties of Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R,S)-(9CI) have not been widely reported, it is not possible to list its applications based on the provided materials. However, given its structural features, it may have potential pharmaceutical applications that warrant further investigation. Once its properties and uses are better understood, it could be employed in various industries, such as:
Used in Pharmaceutical Industry:
Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R,S)-(9CI) could be used as a pharmaceutical agent for [specific application reason], given its structural features and potential for pharmaceutical applications.
Used in Chemical Research Industry:
Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R,S)-(9CI) could be utilized as a research tool in chemical research for [specific research purpose], due to its unique structural properties and chiral nature.

Upstream product

• 46460-23-5 ethyl 2-amino-4-phenyl-(2S)-butyrate 
• 608148-63-6 4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester 
• 577-59-3 2-acetylnitrobenzene 
• 74-96-4 ethyl bromide 
• 127-19-5 N,N-dimethyl acetamide 
• 75-03-6 ethyl iodide 
• 656830-87-4 (R)-2,4-Dihydroxy-4-(2-nitro-phenyl)-butyric acid ethyl ester 
• 608148-58-9 (2R)-2-hydroxy-4-(2-nitrophenyl)-4-oxobutyric acid ethyl ester 
• 608148-60-3 (3R)-3-hydroxy-1,3,4,5-tetrahydrobenzo[b]azepin-2-one 
• 178114-28-8 4-(2-nitrophenyl)-2,4-dioxobutanoic acid ethyl ester 
• 942049-14-1 trans-4-(2-nitrophenyl)-4-oxo-but-2-enoic acid methyl ester 

Relevant articles and documents

Formal synthesis of the ACE inhibitor benazepril·HCl via an asymmetric aza-Michael reaction

A formal enantioselective synthesis of benazepril·HCl (4), an antihypertensive drug, is reported. Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2-nitrophenyl)-4-oxo-but-2-enoic acid methyl est

Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive reaction

An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2S, 3′S)-2-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H- benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4, has been achieved through an asymmetric reduction of 4-(2-nitrophenyl)-2,4-dioxobutyric acid ethyl ester 6b employing baker's yeast as the reductive catalyst.

Kinetic resolution of a intermediate useful in the production of benazepril and analogues thereof

The present invention provides an efficient synthetic process for making benazepril and analogues thereof by having an intermediate compound undergo epimerization and kinetic resolution.

ASYMMETRIC SYNTHESIS OF A KEY INTERMEDIATE FOR MAKING BENAZEPRIL AND ANALOGUES THEREOF

The present invention provides a method of converting an intermediate compound to the desired S,S diastereomer for efficiently making benazepril and analogues thereof.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.