86618-05-5

Basic information

• Product Name: tert-butyl 2-(4-isobutylphenyl)propanoate
• Synonyms: tert-butyl 2-(4-isobutylphenyl)propanoate
• CAS NO: 86618-05-5
• Molecular Weight: 262.392
• Mol File: 86618-05-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-(4-isobutylphenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(4-isobutylphenyl)propanoate(86618-05-5)
• EPA Substance Registry System: tert-butyl 2-(4-isobutylphenyl)propanoate(86618-05-5)

Safety Data

• Hazardous Substances Data: 86618-05-5(Hazardous Substances Data)

Upstream product

• 71381-91-4 (+/-)-2-(4-isobutylphenyl)propanoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 201230-82-2 carbon monoxide 
• 62049-65-4 S-(-)-1-(-)-[4-isobutylphenyl]-chloroethane 
• 15687-27-1 ibuprofen 
• 20487-40-5 tert-butyl propionate 
• 2051-99-2 1-bromo-4-isobutylbenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 138622-99-8 tert-butyl 2-(4-bromophenyl)propionate 
• 106-39-8 bromochlorobenzene 
• 66107-30-0 4-bromophenyl trifluoromethanesulfonate 
• 61658-88-6 4-chloro-1-(2-methylpropyl)benzene 
• 145624-58-4 4-(2-methylpropyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 51407-46-6 2-(4-isobutylphenyl)propionaldehyde 
• 36039-36-8 2-(4-isobutylphenyl)propan-1-ol 
• 15687-27-1 ibuprofen 
• 51146-56-6 (S)-ibuprofen 
• 51146-57-7 (R)-ibuprofene 
• 75-65-0 tert-butyl alcohol 

Relevant articles and documents

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by ethyl 2-(4-bromo-2-chlorophenyl)acetate (3a), can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters.

Effect of group substitution on the physiochemical properties of ibuprofen prodrugs

A series of alkyl ester prodrugs of ibuprofen was synthesized and studied for its physicochemical properties like aqueous solubility, octanol-water partition coefficient and hydrolysis kinetics in aqueous buffer and human plasma. These physicochemical parameters have a forebearing on the overall activity profile of these prodrugs. Mathematical relationships have been derived to characterize these properties.