866404-69-5Relevant academic research and scientific papers
Structural analysis of ATP analogues compatible with kinase-catalyzed labeling
Suwal, Sujit,Senevirathne, Chamara,Garre, Satish,Pflum, Mary Kay H.
, p. 2386 - 2391 (2013/02/23)
Kinase-catalyzed protein phosphorylation is an important biochemical process involved in cellular functions. We recently discovered that kinases promiscuously accept γ-modified ATP analogues as cosubstrates and used several ATP analogues as tools for stud
Phenyl esters, preferred reagents for mono-acylation of polyamines in the presence of water
Pappas, Kyrie,Zhang, Xiang,Tang, Wei,Fang, Shiyue
body text, p. 5741 - 5743 (2009/12/06)
In the presence of water, several diamines and one triamine were mono-acylated at ambient to moderate temperatures using phenyl esters and a phenyl carbonate as acylation agents in good to excellent isolated yields. Both linear and cyclic polyamines were suitable substrates, and the acylating agents can be aryl and alkyl carboxylic acid esters.
Mono-acylation of symmetric diamines in the presence of water
Tang, Wei,Fang, Shiyue
supporting information; scheme or table, p. 6003 - 6006 (2009/04/11)
Simply reacting equal equivalents of symmetric diamines with esters or carbonates in the presence of a suitable amount of water gave mono-acylated products in good to quantitative yields.
GELDANAMYCIN AND DERIVATIVES INHIBIT CANCER INVASION AND IDENTIFY NOVEL TARGETS
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Page/Page column 37; 38, (2008/06/13)
Geldanamycin derivatives that block the uPA-plasmin network and inhibit growth and invasion by glioblastoma cells and other tumors at femtomolar concentrations are potentially highly active anti-cancer drugs. GA and various 17-amino-17-demethoxygelddanamycin derivatives are disclosed that block HGF/SF-mediated Met tyrosine kinase receptor-dependent uPA activation at fM levels. Other ansamycins (macbecins I and II), GA derivatives, and radicicol required concentrations several logs higher (≥nM) to achieve such inhibition. The inhibitory activity of tested compounds was discordant with the known ability of drugs of this class to bind to hsp90, indicating the existence of a novel target(s) for HGF/SF -mediated events in tumor development. Methods of using such compounds to inhibit cancer cell activities and to treat tumors are disclosed. Such treatment with low doses of these highly active compounds provide an option for treating various Met-expressing tumors, in particular invasive brain cancers, either alone or in combination with conventional surgery, chemotherapy, or radiotherapy.
