866523-71-9

Upstream product

• 908834-77-5 5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid methyl ester 
• 52516-13-9 2-(2,4-dichloro-phenyl)-ethylamine 
• 866523-73-1 5-(3-dimethylaminoacryloyl)thiophene-2-carboxylic acid methyl ester 
• 4066-41-5 5-acetylthiophene-2-carboxylic acid 
• 866523-70-8 C₁₈H₁₈Cl₂N₂O₂S 
• 867-44-7 S-Methylisothiourea sulfate 

Downstream Products

• 866523-72-0 5-(2-methanesulfonyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide 

Relevant academic research and scientific papers

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies

A series of 2-pyrimidyl-5-amidothiophenes has been synthesized and evaluated for AKT inhibition. SAR studies resulted in potent inhibitors of AKT with IC50 values as low as single digit nanomolar as represented by compound 2aa. Compound 2aa sho

SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS

The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds