86863-90-3Relevant academic research and scientific papers
Generation and reaction of cyano-substituted aryllithium compounds using microreactors
Nagaki, Aiichiro,Kim, Heejin,Usutani, Hirotsugu,Matsuo, Chika,Yoshida, Jun-Ichi
supporting information; experimental part, p. 1212 - 1217 (2010/06/13)
We developed a microflow method for the generation and reactions of aryllithiums bearing a cyano group, including o-lithiobenzonitrile, m-lithiobenzonitrile and p-lithiobenzonitrile. The method was effective at much higher temperatures than are required for conventional macrobatch reactions, by virtue of rapid mixing, short residence time, and efficient temperature control. In addition, reactions of o-lithiobenzonitrile with carbonyl compounds followed by trapping of the resulting lithium alkoxides with electrophiles were achieved in an integrated microflow system. The Royal Society of Chemistry.
N-cumyl benzamide, sulfonamide, and aryl O-carbamate directed metalation groups. Mild hydrolytic lability for facile manipulation of directed ortho metalation derived aromatics
Metallinos, Costa,Nerdinger, Sven,Snieckus, Victor
, p. 1183 - 1186 (2008/02/09)
(Matrix Presented) N-Cumyl benzamide (2), sulfonamide (8), and O-carbamate (11) compounds undergo directed ortho metalation under standard conditions to give, after quench with a variety of electrophiles, the substituted products 3, 9, and 12, respectively. Regiospecific and convenient approaches to phthalimides (7), 1,2-benzisothiazole 1,1-dioxides (10b), and ortho-substituted phenols (13a) and salicylamides (13b) are thereby established The mild deprotection protocol for these new cumyl directed metalation groups (DMGs) suggests that they will supersede previous corresponding groups for synthetic anionic aromatic chemistry.
Novel Silylation of Aromatic Nitriles via Photo-induced Electron Transfer
Kyushin, Soichiro,Ehara, Yasushi,Nakadaira, Yasuhiro,Ohashi, Mamoru
, p. 279 - 280 (2007/10/02)
Photo-induced electron transfer reactions of hexamethyldisilane and aromatic nitriles have been examined; hexamethyldisilane acts as an effective ?-donor, and undergoes novel photochemical silylation of aromatic nitriles.
