2-TRIMETHYLYSILYLBENZONITRILE

Base Information

• Chemical Name: 2-TRIMETHYLYSILYLBENZONITRILE
• CAS No.: 86863-90-3
• Molecular Formula: C10H13 N Si
• Molecular Weight: 175.305
• Hs Code.: 2931900090
• Mol file: 86863-90-3.mol

Synonyms:2-Trimethylsilylbenzonitrile;2-TRIMETHYLYSILYLBENZONITRILE;2-Trimethlysilanylbenzonitrile

Chemical Property of 2-TRIMETHYLYSILYLBENZONITRILE

Chemical Property:

• PSA: 23.79000
• LogP: 2.10348

Purity/Quality:

97% ^*data from raw suppliers

2-TRIMETHYLYSILYLBENZONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-TRIMETHYLYSILYLBENZONITRILE

There total 7 articles about 2-TRIMETHYLYSILYLBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

chloro-trimethyl-silane (75-77-4) + benzonitrile (100-47-0) → 2-(trimethylsilyl)benzonitrile (86863-90-3) + 2,6-Bis-trimethylsilanyl-benzonitrile (86863-89-0)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at 0 ℃; for 0.25h;

DOI:10.1021/ja00357a034

Reference yield: 51.0%

N-(2-phenylpropan-2-yl)-2-(trimethylsilyl)benzamide (249764-72-5) → 2-(trimethylsilyl)benzonitrile (86863-90-3)

Guidance literature:

N-(2-phenylpropan-2-yl)-2-(trimethylsilyl)benzamide; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -40 - 0 ℃; for 7h;

With ethanol; In dichloromethane; at 20 ℃; for 18h; Further stages.;

DOI:10.1021/ol990846b

Reference yield: 10.0%

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + phthalonitrile (91-15-6) → 2-(trimethylsilyl)benzonitrile (86863-90-3)

Guidance literature:

for 1h; Irradiation;

DOI:10.1039/c39890000279

upstream raw materials:

chloro-trimethyl-silane

benzonitrile

1,1,1,2,2,2-hexamethyldisilane

phthalonitrile

Refernces

• 1、 Metallinos, Costa,Nerdinger, Sven,Snieckus, Victor. "N-cumyl benzamide, sulfonamide, and aryl O-carbamate directed metalation groups. Mild hydrolytic lability for facile manipulation of directed ortho metalation derived aromatics". . p. 1183 - 1186. Retrieved 2008/02/09.
• 2、 Krizan, Timothy D.,Martin, J. C.. "In Situ Trapping of Ortho-Lithiated Benzenes Containing Electrophilic Directing Groups". . p. 6155 - 6157. Retrieved 2007/10/02.