86906-05-0

Basic information

• Product Name: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL
• Synonyms: (2R)-1,1,3-Triphenyl-2-amino-1-propanol;(R)-2-Amino-1,1,3-triphenyl-1-propanol,99%e.e.;(R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL
• CAS NO: 86906-05-0
• Molecular Formula: C₂₁H₂₁NO
• Molecular Weight: 303.4
• Product Categories: Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 86906-05-0.mol

Chemical Properties

• Melting Point: 142-144 °C(lit.)
• Boiling Point: 502.3 ºC at 760 mmHg
• Flash Point: 257.6 ºC
• Appearance: /
• Density: 1.145 g/cm³
• Vapor Pressure: 6.57E-11mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL(86906-05-0)
• EPA Substance Registry System: (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL(86906-05-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 86906-05-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL is used as a chiral building block for the synthesis of various pharmaceutical compounds. Its unique R-configuration and reactivity make it a valuable component in the development of new drugs with specific biological activities.
Used in Chemical Synthesis:
(R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL is used as a chiral catalyst or ligand in asymmetric synthesis, enabling the selective formation of enantiomerically pure compounds. Its chirality and reactivity contribute to the development of efficient and enantioselective synthetic methods.
Used in Research and Development:
(R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL is used as a research compound to study the effects of chirality on biological activity and stereoselectivity in chemical reactions. Its unique properties make it a valuable tool for understanding the role of stereochemistry in various chemical and biological processes.
Used in Industrial Applications:
(R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL is used as an intermediate in the synthesis of various industrial chemicals, such as chiral pharmaceuticals, agrochemicals, and specialty chemicals. Its high stability and potential for aromatic interactions make it a suitable candidate for the development of new industrial products.

InChI:InChI=1/C21H21NO/c22-20(16-17-10-4-1-5-11-17)21(23,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20,23H,16,22H2/t20-/m1/s1

Upstream product

• 673-06-3 D-(R)-phenylalanine 
• 21685-51-8 D-phenylalanine methyl ester 
• 57728-37-7 DL-2-Amino-1,1,3-triphenyl-1-propanol 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 191274-51-8 (R)-4,4-diphenyl-5-benzyloxazolidin-2-thione 
• 694520-57-5 (R)-N-acetyl-4,4-diphenyl-5-benzyloxazolidin-2-thione 
• 694520-62-2 1-((R)-4-Benzyl-5,5-diphenyl-2-thioxo-oxazolidin-3-yl)-2-{(2S,5S)-5-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-pentyl]-tetrahydro-furan-2-yl}-ethanone 
• 1023625-72-0 2-hydroxybenzaldehyde ((2R)-1,1,3-triphenylpropanol) imine 
• 1318762-59-2 (S,S)-2-amino-N-(1-hydroxy-1,1,3-triphenylpropan-2-yl)-3-methylbutanamide 
• 1318762-61-6 (S,R)-2-amino-N-(1-hydroxy-1,1,3-triphenylpropan-2-yl)-4-methylpentanamide 
• 1399169-34-6 C₈₂H₆₀N₂O₂ 
• 57728-37-7 DL-2-Amino-1,1,3-triphenyl-1-propanol 

Relevant articles and documents

Direct asymmetric N-specific reaction of nitrosobenzene with aldehydes catalyzed by a chiral primary amine-based organocatalyst

Nitroso compounds have two reactive nitrogen and oxygen atoms. It is interesting and important to perform a nitrogen or oxygen selective reaction with interesting substrates. These atom specific reactions are crucial to specifically synthesis of specific compounds. An enantioselective N-specific reaction of nitrosobenzene with unmodified aldehydes was successfully achieved catalyzed first by a variety of primary amine-based organocatalysts with higher yield and enantioselectivity. The bulkier substituted groups of the organocatalyst and two hydrogen bonds from the organocatalyst and the oxygen atom of nitrosobenzene make the reaction preferentially N-specific and predominantly afford R products.

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

Highly Diastereoselective Synthesis of trans-2,5-Disubstituted Tetrahydrofurans

trans-2,5-Disubstituted tetrahydrofurans were obtained as major diastereomers (trans / cis ratio 90:10-100: 0) when acetylated y-lactols derived from (S)-glutamic acid were treated with titanium enolates of N-acetyl (R)-oxazolidin-2-thiones. A simple tran