869219-33-0

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 64-19-7 acetic acid 
• 356533-73-8 4-(4-isocyanophenyl)morpholine 
• 64-18-6 formic acid 
• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 10389-51-2 1-morpholino-4-nitrobenzene 
• 144-62-7 oxalic acid 

Downstream Products

• 356533-73-8 4-(4-isocyanophenyl)morpholine 
• 1269206-10-1 (4-chlorophenyl)[1-(4-morpholinophenyl)-1H-tetrazol-5-yl]methanone 
• 1269205-95-9 (4-chlorophenyl)[1-(4-morpholinophenyl)-1H-tetrazol-5-yl]methanamine 
• 1269205-88-0 N-benzyl-1-(4-chlorophenyl)-1-[1-(4-morpholinophenyl)-1H-tetrazol-5-yl]methanamine 

Relevant academic research and scientific papers

Supported Palladium Nanoparticles Catalyzed Reductive Carbonylation of Nitroarenes to N-Arylformamides

A facile reductive carbonylation reaction of nitroarenes to N-arylformamide synthesis was investigated under polymer supported palladium (Pd@PS) nanoparticles catalyzed conditions. Dual role of oxalic acid dihydrate ((CO2H)2 ? 2H2O) as H2 source for hydrogenation and CO source for carbonylation reaction for desired products synthesis was critically investigated under favorable DMF solvent conditions. Several cross experiments were performed to establish the best possible hypothesis for the proposed mechanism and understanding about the involvement of CO in the reaction pathway. Further, ortho-substituted nitroarenes were found to be highly specific for facile para-hydroxylation to give corresponding para-hydroxy N-aryl formamides. (Figure presented.).

MORPHOLINYLANILINOQUINAZO- LINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS

Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses, wherein R1, R2, R3 and R4 are as defined in the claims.

Acceleration of the Passerini reaction in the presence of nucleophilic additives

An accelerating effect of nucleophilic additives was revealed for the Passerini multi-component reaction. The influence of aqueous solutions on the reaction rate was studied in detail and the direct involvement of water in the bond-making step was attributed as the basis of an accelerating effect. Other nucleophiles were tested as alternatives to water; as a result N-hydroxysuccinimide is proposed as an accelerant of the Passerini reaction.