86978-99-6

Basic information

• Product Name: Ethanol, 2-[[1-(phenylmethyl)-1H-benzimidazol-2-yl]amino]-
• CAS NO: 86978-99-6
• Molecular Formula: C16H17N3O
• Molecular Weight: 267.33
• Mol File: 86978-99-6.mol

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[[1-(phenylmethyl)-1H-benzimidazol-2-yl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[[1-(phenylmethyl)-1H-benzimidazol-2-yl]amino]-(86978-99-6)
• EPA Substance Registry System: Ethanol, 2-[[1-(phenylmethyl)-1H-benzimidazol-2-yl]amino]-(86978-99-6)

Safety Data

• Hazardous Substances Data: 86978-99-6(Hazardous Substances Data)

Upstream product

• 4857-06-1 2-chloro-1H-benzoimidazole 
• 88-74-4 2-nitro-aniline 
• 100-39-0 benzyl bromide 
• 141-43-5 ethanolamine 
• 43181-78-8 1-benzyl-2-chlorobenzimidazole 
• 28643-53-0 1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one 
• 5822-13-9 N-benzyl-1,2-phenylenediamine 
• 90331-20-7 1-Benzylbenzimidazole-2-sulfonic Acid 

Downstream Products

• 111678-96-7 (1-Benzyl-1H-benzoimidazol-2-yl)-(2-chloro-ethyl)-amine 
• 24134-56-3 9-Benzyl-2,3-dihydroimidazo<1,2-a>benzimidazole 
• 111679-18-6 1-Benzyl-2-(2-methoxyethylamino)benzimidazole 

Relevant articles and documents

Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

A high-throughput (HTS) and high-content screening (HCS) campaign of a commercial library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogues as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which have been known as the causative parasites for visceral leishmaniasis and Chagas disease, respectively. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds 4 and 24 showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, respectively) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 μM, respectively) without serious cytotoxicity toward THP-1 and U2OS cell lines.

Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

A high-throughput (HTS) and high-content screening (HCS) campaign of a commercial library identified 2,3-dihydroimidazo[1,2-a]benzimidazole analogues as a novel class of anti-parasitic agents. A series of synthetic derivatives were evaluated for their in vitro anti-leishmanial and anti-trypanosomal activities against Leishmania donovani and Trypanosoma cruzi, which have been known as the causative parasites for visceral leishmaniasis and Chagas disease, respectively. In the case of Leishmania, the compounds were tested in both intracellular amastigote and extracellular promastigote assays. Compounds 4 and 24 showed promising anti-leishmanial activity against intracellular L. donovani (3.05 and 5.29 μM, respectively) and anti-trypanosomal activity against T. cruzi (1.10 and 2.10 mM, respectively) without serious cytotoxicity toward THP-1 and U2OS cell lines.

RESEARCH ON IMIDAZOBENZIMIDAZOLE DERIVATIVES. 23. SYNTHESES BASED ON 2-(2-HYDROXYETHYLAMINO)BENZIMIDAZOLES

The possibility of annelation of the imidazoline ring on the basis of 2(2-hydroxyethylamino)-benzimidazoles was studied.It was shown that the action of hydrobromic, sulfuric, nitrosylsulfuric, and polyphosphoric acids, acetic anhydride, and phosphorus oxychloride on them does not lead to 2,3-dihydroimidazo-benzimidazoles.In the case of POCl3 the products were 2-(2-chloroethylamino)benzimidazoles, treatment of which with alcoholic alkali led primarily to nucleophilic substitution of the chlorine atom by a methoxy group.Three-ring imidazolines are formed in 12-15percent yields in this case.It was established that the reaction proceeds through the intermediate formation of aziridine derivatives.