872850-48-1

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester
• CAS NO: 872850-48-1
• Molecular Formula: C12H20N2O3
• Molecular Weight: 240.302
• Mol File: 872850-48-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester(872850-48-1)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester(872850-48-1)

Safety Data

• Hazardous Substances Data: 872850-48-1(Hazardous Substances Data)

Upstream product

• 26386-88-9 diphenyl phosphoryl azide 
• 188792-67-8 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid 
• 189442-87-3 ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate 
• 189321-63-9 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 

Downstream Products

• 828935-40-6 tert-butyl 4-(2-(((S)-1-methoxy-1-oxopropan-2-yl)((S)-1-(4-trifluoromethylphenyl)ethyl)amino)-2-oxoethylamino)-4-methyl-piperidine-1-carboxylate 
• 741687-12-7 4-methyl-4-{3-methyl-2,5-dioxo-4-[1-(4-trifluoromethylphenyl)ethyl]piperazin-1-yl}piperidine-1-carboxylic acid tert-butyl ester 
• 544704-12-3 2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine 
• 306293-41-4 Sch 350634 

Relevant articles and documents

Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists

4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step. The alkylation of isonipecotate could introduce various substituents at the 4-position of the piperidine ring. With this key building block, we are able to efficiently synthesize piperazino-piperidine based CCR5 antagonist in a highly convergent manner free of using toxic reagents such as diethylaluminum cyanide. The concise synthesis of a potent bioavailable CCR5 antagonist as HIV-1 entry inhibitor, Sch-350634 (1) was accomplished in excellent yield using N′-Boc-4-methyl-4-aminopiperidine 5a as a smart building block. The new methodology provides a facile and practical access to the piperazino-piperidine amide analogs as HIV-1 entry inhibitors.

NOVEL PIPERIDINE/8-AZABICYCLO [3.2.1] OCTAN DERIVATIVES AS MODUILATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).