872850-48-1

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester
• CAS NO: 872850-48-1
• Molecular Formula: C12H20N2O3
• Molecular Weight: 240.302
• Mol File: 872850-48-1.mol

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester(872850-48-1)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-isocyanato-4-methyl-, 1,1-dimethylethyl ester(872850-48-1)

Safety Data

• Hazardous Substances Data: 872850-48-1(Hazardous Substances Data)

Upstream product

• 26386-88-9 diphenyl phosphoryl azide 
• 188792-67-8 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 189442-87-3 ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate 
• 189321-63-9 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid 

Downstream Products

• 828935-40-6 tert-butyl 4-(2-(((S)-1-methoxy-1-oxopropan-2-yl)((S)-1-(4-trifluoromethylphenyl)ethyl)amino)-2-oxoethylamino)-4-methyl-piperidine-1-carboxylate 
• 741687-12-7 4-methyl-4-{3-methyl-2,5-dioxo-4-[1-(4-trifluoromethylphenyl)ethyl]piperazin-1-yl}piperidine-1-carboxylic acid tert-butyl ester 
• 544704-12-3 2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine 
• 306293-41-4 Sch 350634 

Relevant articles and documents

Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists

4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step. The alkylation of isonipecotate could introduce various substituents at the 4-position of the piperidine ring. With this key building block, we are able to efficiently synthesize piperazino-piperidine based CCR5 antagonist in a highly convergent manner free of using toxic reagents such as diethylaluminum cyanide. The concise synthesis of a potent bioavailable CCR5 antagonist as HIV-1 entry inhibitor, Sch-350634 (1) was accomplished in excellent yield using N′-Boc-4-methyl-4-aminopiperidine 5a as a smart building block. The new methodology provides a facile and practical access to the piperazino-piperidine amide analogs as HIV-1 entry inhibitors.

AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment

NOVEL PIPERIDINE/8-AZABICYCLO [3.2.1] OCTAN DERIVATIVES AS MODUILATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).