873386-83-5Relevant articles and documents
A 1-chloro-3-bromo-5-iodophenylamino preparation method
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Paragraph 0016, (2016/12/01)
This invention relates to a kind of 1-chloro-3-bromo-5-iodophenylamino preparation method, comprising the following steps: step one, in a container into the to iodine aniline and anhydrous ethanol, under normal temperature conditions, batch by adding bromine-chlorine-dimethyl hydantoin; HPLC print detection no raw material product, stopping reaction; can be directly filtered to obtain 2-chloro-4-bromo-6-iodo aniline intermediates; stated, in another container into the 2-chloro-4-bromo-6-iodo aniline intermediate and secondary phosphate, sodium nitrite solution dropwise after cooling, there will be after the end of the dropping solid wash-out, direct filter, recrystallized with absolute ethanol to obtain acicular 1-chloro-3-bromo-5-iodophenylamino. The present invention improves operating environment of production, at the same time adopts a low priced bromine-chlorine-dimethyl hydantoin as the solvent for preparing the product, and is easy to operate and control, and the yield is improved, but also shortens the reaction time, the cost is reduced, which is beneficial for industrial production.