875241-65-9Relevant academic research and scientific papers
COMPOUNDS COMPRISING N-METHYL-2-PYRIDONE, AND PHARMACEUTICALLY ACCEPTABLE SALTS
-
Page/Page column 51; 53, (2020/12/30)
The present invention concerns compounds comprising N-methyl-2-pyridone, and pharmaceutically-acceptable salts and compositions of such compounds. Such compounds are useful in anti-inflammatory and anti-cancer therapies. Therefore, the present invention also concerns such compounds for use as medicaments, particularly for the treatment of inflammatory diseases and oncology.
The effect of the leaving group in n-heterocyclic carbene-catalyzed nucleophilic aromatic substitution reactions
Yasui, Kosuke,Kamitani, Miharu,Fujimoto, Hayato,Tobisu, Mamoru
, p. 1424 - 1429 (2020/12/28)
We report here that the reactivity order of the leaving group is F > Cl 2 Br > I in N-heterocyclic carbene-catalyzed CSNAr reactions of aryl halides bearing an α,β-unsaturated amide. Based on a qualitative Marcus analysis, the nature
