875296-11-0Relevant academic research and scientific papers
DIKETO ACIDS WITH NUCLEOBASE SCAFFOLDS: ANTI-HIV REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE IN COMBINATION THERAPY
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Page/Page column 47-48, (2008/06/13)
A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HFV and in the treatmen
HIV integrase inhibitors with nucleobase scaffolds: Discovery of a highly potent anti-HIV agent
Nair, Vasu,Chi, Guochen,Ptak, Roger,Neamati, Nouri
, p. 445 - 447 (2007/10/03)
HIV integrase is essential for HIV replication. However, there are currently no integrase inhibitors in clinical use for AIDS. We have discovered a conceptually new β-diketo acid that is a powerful inhibitor of both the 3′-processing and strand transfer s
Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
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Page/Page column 12, (2008/06/13)
A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatmen
Diketo acids on nucleobase scaffolds as inhibitors of Flaviviridae
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Page/Page column 12, (2010/11/24)
A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HCV replication through inhibition of HCV NS5B RNA polymerase, is described. These compounds are useful in the prevention or treatment of infection by HCV and in th
