87604-59-9

Upstream product

• 87604-57-7 (R)-2-(benzyloxy)-2-phenylacetaldehyde 
• 20780-54-5 (S)-styrene oxide 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 156480-57-8 (2S,4S,5R)-2-((R)-Benzyloxy-phenyl-methyl)-4-methyl-5-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 100349-67-5 (1S)-2-iodo-1-phenylethanol 
• 40435-14-1 (S)-1-phenyl-2-(tosyloxy)ethanol 
• 16354-89-5 (R)-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl](phenyl)methanol 
• 100-52-7 benzaldehyde 
• 186414-20-0 Phenyl-[(2R,4aR,6S,7R,8S,8aR)-6,7,8-trimethoxy-3-(toluene-4-sulfonyl)-octahydro-pyrano[2,3-e][1,3]oxazin-2-yl]-methanone 
• 186414-25-5 (R)-Phenyl-[(2R,4aR,6S,7R,8S,8aR)-6,7,8-trimethoxy-3-(toluene-4-sulfonyl)-octahydro-pyrano[2,3-e][1,3]oxazin-2-yl]-methanol 
• 216760-16-6 (R)-2-((R)-Benzyloxy-phenyl-methyl)-4,4-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 216760-01-9 (R)-2-((R)-Hydroxy-phenyl-methyl)-4,4-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 93-56-1 phenylethane 1,2-diol 

Downstream Products

• 1434644-20-8 C₃₀H₃₃BrN₂O₅S 

Relevant academic research and scientific papers

Alkylative kinetic resolution of vicinal diols under phase-transfer conditions: A chiral ammonium borinate catalysis

Herein, we report the first alkylative kinetic resolution of vicinal alcohols realized by cooperative use of a chiral quaternary ammonium salt and an achiral borinic acid. In addition, a catalytic regioselective alkylation of a secondary alcohol in the presence of an unprotected primary one is presented, emphasizing the unique selectivity and potential of this ammonium borinate catalysis.

ACC INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Formation and reaction of 2-metalated N-Boc-4,4-dimethyl-1,3- oxazolidines in the presence of (-)-sparteine: New chiral formyl anion equivalents

Lithiation of N-Boc-4,4-dimethyl-1,3-oxazolidine with s-BuLi and the following reaction with benzaldehyde was carried out in the presence of (-)- sparteine. The reaction was not diastereoselective (syn:anti=46:54), but each isomer of the adducts was obtai

Diastereoselective reduction of chiral N-tosyl 2-benzoyl-1,3-oxazines derived from D-glucose

Stereochemistry of reduction of the diastereomerically pure N-tosyl 2-benzoyl-1,3-oxazines prepared from D-glucose was investigated with various reducing agents. It was found that the stereachemical outcome is consistent with the Cram's chelation model where the ring oxygen atom is involved in chelation, not the tosyl oxygen as in the 5-membered oxazolidines.

Chiral 2-lithio-13-dioxolanes and - 2-lithiooxazolidines: New formyl anion equivalents

The preparation of enantiomerically pure 2-lithio-1,3-dioxolanes and 2-lithiooxazolidines and their use as formyl anion equivalents in addition reactions to aldehydes are described.

Oxirane Ring-Opening with Alcohol Catalyzed by Organotin Phosphate Condensates. Complete Inversion at Tertiary and Benzylic Centers

Regio- and stereospecific ring-opening of chiral oxiranes has been effected by organotin phosphate condensates catalyst.Alcohols attack on the tertiary and benzylic positions exclusively.Despite seemingly acidic character of the catalyst in terms of regioselectivity the chiral centers are completely inverted.The new methodology is applied to synthesis of enantiomerically pure linalool and to conversion of commercially available (R)-styrene oxide into the (S)-counterpart.

ON THE STERIC COURSE OF THE ADDITION OF SOME ORGANOMETALLIC REAGENTS TO (R)-2,3-ISOPROPYLIDENE GLYCERALDEHYDE. SYNTHESIS OF OPTICALLY ACTIVE α-BENZYLOXY ALDEHYDES, ALCOHOLS, CARBOXYLIC ACIDS AND 1,2-DIOLS.

Organo-titanium and organo-zinc reagents were added stereoselectively to (R)-2,3-isopropylidene glyceraldehyde (1) to give the alcohols 2/3, which were converted into the optically active derivatives 4-11.