87779-57-5

Usage

Uses

Used in Organic Synthesis:
8-BROMO-1,2-DIHYDRONAPHTHALENE is used as a building block in organic synthesis for the preparation of various other chemical compounds. Its versatility in undergoing different chemical reactions makes it a valuable component in creating a range of products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 8-BROMO-1,2-DIHYDRONAPHTHALENE is used as a key intermediate in the production of various pharmaceuticals. Its role in the synthesis of medicinal compounds highlights its importance in developing new drugs and improving existing ones.
Used in Agrochemical Production:
8-BROMO-1,2-DIHYDRONAPHTHALENE also finds application in the agrochemical sector, where it is used in the synthesis of various agrochemicals. Its contribution to the development of agricultural chemicals aids in enhancing crop protection and productivity.
Used in Fine Chemicals Production:
8-BROMO-1,2-DIHYDRONAPHTHALENE is utilized in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors. Its role in fine chemicals production underscores its importance in creating high-quality specialty products.
Safety and Handling:

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 1074-15-3 1-bromo-2-(2-bromoethyl)benzene 
• 92013-31-5 5-bromotetralol 
• 68449-30-9 5-bromo-1-tetralone 
• 18698-97-0 ortho-bromophenylacetic acid 
• 92013-29-1 2-(2-(o-bromophenyl)ethyl)-malonic acid 
• 1074-16-4 2-bromophenylethyl alcohol 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 92013-30-4 4-(o-bromophenyl)butyryl chloride 
• 90841-47-7 4-(2-bromophenyl)butanoic acid 
• 92013-28-0 1,1-bis(ethoxycarbonyl)-3-(2'-bromophenyl)propane 

Downstream Products

• 132095-53-5 5-Bromo-2-oxo-1,2,3,4-tetrahydronaphthalene 
• 66325-42-6 5-n-butyltetralin 
• 42775-75-7 5-ethyltetralin 

Relevant academic research and scientific papers

SEROTONIN RECEPTOR MODULATORS

Compounds, compositions, and methods are provided for dual partial agonism of serotonin 5-HT7 and 5-HT1A receptors. The enantiomerically pure 5-phenyl-2-aminotetralin (5-PAT) compounds can be used to treat or prevent substance use disorder, opioid use disorder, addiction, anxiety, psychosis, depression, autism spectrum disorder, fragile X syndrome, neurological disorders, neuropsychiatric disorders, repetitive behaviors, movement disorders, compulsions, tics, pain disorders, vasospastic disorders, migraine headache, seizures, epilepsy, social anxiety, addiction withdrawal, drug withdrawal, drug abuse, alcoholism, eating disorders, general inflammation disorders, miosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and gastrointestinal disorders.

COMPOUNDS AND METHODS FOR MODULATING SEROTONIN RECEPTORS IN THE PERIPHERY

This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the Gl tract.

SEROTONIN RECEPTOR-TARGETING COMPOUNDS AND METHODS

This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine deriva

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

Various racemic and enantioenriched (trans)-X,Y-dihydroxy-X,Y-dihydronaphthoyl analogues as well as X-hydroxy-naphthoyl analogues of CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (1, Setipiprant/ACT-129968) were synthesized in order to gain insight into regio- and enantioselectivity of the metabolic oxidation of 1 and to verify the structures of four metabolites that were proposed earlier in a clinical ADME study. Analytical data of the synthetic standards were compared with data from samples of biological origin. The two major metabolites M7 and M9 were unambiguously verified as 2-(2-((trans)-3,4-dihydroxy-3,4-dihydronaphthalene-1-carbonyl)- and 2-(2-((trans)-5,6-dihydroxy-5,6-dihydronaphthalene-1-carbonyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid, respectively, each composed of two enantiomers with 68% and 44% ee in favor of (+)-(3S,4S)-M7 and (+)-(5S,6S)-M9, respectively. Likewise, minor metabolites M3 and M13 were identified as 2-(8-fluoro-2-(5-hydroxy-1-naphthoyl)- and 2-(8-fluoro-2-(4-hydroxy-1-naphthoyl)-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetic acid, respectively.

Synthesis of Biological Markers in Fossil Fuels. 2. Synthesis and 13C NMR Studies of Substituted Indans and Tetralins

Unambiguous syntheses of all possible methyl, ethyl, n-propyl, and n-butyl derivatives of indan and tetralin were developed using the Kumada coupling procedure involving the reaction of aryl or vinyl halides with Grignard reagents in the presence of nickel(II) chloride.An analysis of the 13C NMR spectra of these compounds was also completed.

Hydrocarbures arylaliphatiques. Partie VII. Orientation dans la reaction de bromation de benzocyclenes bi- et tricycliques superieurs

The bromination of 1,2,3-trimethylbenzene, and bi- and tricyclic fused ring systems (i.e. indan, tetralin, benzosuberan, 2a,3,4,5-tetrahydroacenaphthen and higher homologues) is described in this paper.This work is part of a research project studying the ring size influence of peri-fused semi-aromatic ring system on benzene reactivity.This study was started in a first step on acetylation and was continued on bromination.Forthcoming studies (now underway) concern the kinetic measurement of protodesilylation of univocal silyl derivatives.The synthesis of the starting bromo derivatives used for this latter study is described here.These bromides were used for the attribution via NMR spectroscopy of the electrophile reaction site in the direct bromination of the fused ring unsymmetrical systems (the reactive sites are obvious in symmetrical molecules). Thus, meta substitution is predominant in the case of tetraline and benzosuberan, but ortho substitution is relatively more important in tetralin.In 1,2,3-trimethylbenzene and the fused tricyclic compounds, substitution takes place in an ortho position respective to the substituent or the ring system, the meta position being totally deactivated.In the special case of a five-membered ring, the ortho position this ring is always non reactive.The reactivity differences between these compounds are explained by hyper conjugation and the stabilities of the transition states.