92013-31-5

Usage

Uses

Used in Organic Synthesis:
5-BROMO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL is used as a building block in organic synthesis for its ability to be modified and incorporated into more complex molecules. Its unique structure and reactivity make it a valuable component in the creation of various organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-BROMO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL is used as a key intermediate in the development of new drugs. Its properties allow it to be a precursor to potential therapeutic agents, contributing to the advancement of medicinal chemistry.
Used in Fragrance and Flavor Industry:
5-BROMO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL is used as a starting material in the production of fragrance and flavor compounds. Its characteristic odor and chemical properties make it suitable for creating a wide range of scents and tastes used in various consumer products.
Used in Chemical Research:
In the field of chemical research, 5-BROMO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL is utilized as a model compound to study various chemical reactions and mechanisms. Its unique structure provides insights into the behavior of brominated organic compounds and their interactions with other molecules.
Used in Material Science:
5-BROMO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL is employed in material science for its potential applications in the development of new materials with specific properties. Its chemical structure can be tailored to create materials with unique characteristics, such as improved stability or enhanced performance in various applications.

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 1074-15-3 1-bromo-2-(2-bromoethyl)benzene 
• 68449-30-9 5-bromo-1-tetralone 
• 92013-29-1 2-(2-(o-bromophenyl)ethyl)-malonic acid 
• 92013-30-4 4-(o-bromophenyl)butyryl chloride 
• 90841-47-7 4-(2-bromophenyl)butanoic acid 
• 92013-28-0 1,1-bis(ethoxycarbonyl)-3-(2'-bromophenyl)propane 
• 1074-16-4 2-bromophenylethyl alcohol 
• 18698-97-0 ortho-bromophenylacetic acid 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 

Downstream Products

• 132095-53-5 5-Bromo-2-oxo-1,2,3,4-tetrahydronaphthalene 
• 66325-42-6 5-n-butyltetralin 
• 42775-75-7 5-ethyltetralin 
• 87779-57-5 bromo-5 dihydro-3,4 naphthalene 

Relevant academic research and scientific papers

SEROTONIN RECEPTOR MODULATORS

Compounds, compositions, and methods are provided for dual partial agonism of serotonin 5-HT7 and 5-HT1A receptors. The enantiomerically pure 5-phenyl-2-aminotetralin (5-PAT) compounds can be used to treat or prevent substance use disorder, opioid use disorder, addiction, anxiety, psychosis, depression, autism spectrum disorder, fragile X syndrome, neurological disorders, neuropsychiatric disorders, repetitive behaviors, movement disorders, compulsions, tics, pain disorders, vasospastic disorders, migraine headache, seizures, epilepsy, social anxiety, addiction withdrawal, drug withdrawal, drug abuse, alcoholism, eating disorders, general inflammation disorders, miosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and gastrointestinal disorders.

Development of Novel Phosphino-Oxazoline Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides

A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)benzoic acid were developed. Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical coupling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclic α-halides and α-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions. With multi distinct sites for structural modification, a diverse pool of chiral N,N,P-ligands is readily accessed, allowing for rapid optimization of the ligand structure for a specific substrate. Notably, the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.

COMPOUNDS AND METHODS FOR MODULATING SEROTONIN RECEPTORS IN THE PERIPHERY

This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the Gl tract.

SEROTONIN RECEPTOR-TARGETING COMPOUNDS AND METHODS

This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine deriva

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

Various racemic and enantioenriched (trans)-X,Y-dihydroxy-X,Y-dihydronaphthoyl analogues as well as X-hydroxy-naphthoyl analogues of CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (1, Setipiprant/ACT-129968) were synthesized in order to gain insight into regio- and enantioselectivity of the metabolic oxidation of 1 and to verify the structures of four metabolites that were proposed earlier in a clinical ADME study. Analytical data of the synthetic standards were compared with data from samples of biological origin. The two major metabolites M7 and M9 were unambiguously verified as 2-(2-((trans)-3,4-dihydroxy-3,4-dihydronaphthalene-1-carbonyl)- and 2-(2-((trans)-5,6-dihydroxy-5,6-dihydronaphthalene-1-carbonyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid, respectively, each composed of two enantiomers with 68% and 44% ee in favor of (+)-(3S,4S)-M7 and (+)-(5S,6S)-M9, respectively. Likewise, minor metabolites M3 and M13 were identified as 2-(8-fluoro-2-(5-hydroxy-1-naphthoyl)- and 2-(8-fluoro-2-(4-hydroxy-1-naphthoyl)-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetic acid, respectively.

Synthesis of Biological Markers in Fossil Fuels. 2. Synthesis and 13C NMR Studies of Substituted Indans and Tetralins

Unambiguous syntheses of all possible methyl, ethyl, n-propyl, and n-butyl derivatives of indan and tetralin were developed using the Kumada coupling procedure involving the reaction of aryl or vinyl halides with Grignard reagents in the presence of nickel(II) chloride.An analysis of the 13C NMR spectra of these compounds was also completed.