877814-52-3Relevant academic research and scientific papers
NK1 antagonists based on seven membered lactam scaffolds
Elliott, Jason M.,Carlson, Emma J.,Chicchi, Gary G.,Dirat, Olivier,Dominguez, Maria,Gerhard, Ute,Jelley, Richard,Jones, A. Brian,Kurtz, Marc M.,Tsao, Kwei lan,Wheeldon, Alan
, p. 2929 - 2932 (2006)
A new class of high affinity hNK1R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo prope
Expeditious synthesis of novel NK1 antagonists based on a 1,2,4-trisubstituted cyclohexane
Dirat, Olivier,Elliott, Jason M.,Jelley, Richard A.,Jones, A. Brian,Reader, Michael
, p. 1295 - 1298 (2007/10/03)
A stereoselective asymmetric route to novel potent NK1 antagonists based on a 1,2,4-trisubstituted cyclohexane core is discussed.
