20950-96-3

Basic information

• Product Name: phenyl N-(4-methoxyphenyl)carbamate
• Synonyms: phenyl N-(4-methoxyphenyl)carbamate;PHENYL N-(P-ANISYL)CARBAMATE;(4-methoxyphenyl)carbamic acid phenyl ester
• CAS NO: 20950-96-3
• Molecular Formula: C₁₄H₁₃NO₃
• Molecular Weight: 243.2579
• Mol File: 20950-96-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 151 °C
• Boiling Point: 355.5°Cat760mmHg
• Flash Point: 168.8°C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 3.12E-05mmHg at 25°C
• Refractive Index: 1.61
• PKA: 12.44±0.70(Predicted)
• CAS DataBase Reference: phenyl N-(4-methoxyphenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl N-(4-methoxyphenyl)carbamate(20950-96-3)
• EPA Substance Registry System: phenyl N-(4-methoxyphenyl)carbamate(20950-96-3)

Safety Data

• Hazardous Substances Data: 20950-96-3(Hazardous Substances Data)

Usage

General Description

Phenyl N-(4-methoxyphenyl)carbamate is an organic chemical compound with the molecular formula C15H15NO3. It is also known by the trade name "4-Methoxyphenyl N-phenylcarbamate" and is used as a pharmaceutical intermediate in the synthesis of various drugs. phenyl N-(4-methoxyphenyl)carbamate is a white to off-white solid that is soluble in organic solvents and is stable under normal conditions. It has been studied for its potential applications in the treatment of various diseases and disorders, but its specific pharmacological and toxicological properties are not well-documented. Additionally, phenyl N-(4-methoxyphenyl)carbamate may be a potential irritant to the skin, eyes, and respiratory system, and proper safety precautions should be taken when handling and using this chemical.

InChI:InChI=1/C14H13NO3/c1-17-12-9-7-11(8-10-12)15-14(16)18-13-5-3-2-4-6-13/h2-10H,1H3,(H,15,16)

Upstream product

• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 1170292-50-8 phenyl (2,4,6-trinitrophenyl) carbonate 
• 104-94-9 4-methoxy-aniline 
• 103-90-2 4-acetaminophenol 
• 123-30-8 4-amino-phenol 
• 10349-38-9 p-methoxyphenylisonitrile 
• 108-95-2 phenol 
• 1202680-24-7 phenyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate 
• 3532-17-0 4-methoxybenzoyl azide 
• 1885-14-9 phenyl chloroformate 
• 35180-03-1 chloromethyl phenyl carbonate 
• 64897-42-3 phenyl 2,4-dinitrophenyl carbonate 
• 5416-93-3 4-Methoxyphenyl isocyanate 

Downstream Products

• 1321896-75-6 4-{4-[3-(4-methoxyphenyl)ureido]phenoxy}pyridine-2-carboxylic acid methylamide 
• 1227-44-7 N,N'-bis(4-methoxyphenyl)urea 
• 87919-18-4 1-(2-hydroxyethyl)-3-(4-methoxyphenyl)urea 
• 1287216-28-7 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde 4-(4-methoxyphenyl)semicarbazone 
• 62774-59-8 N-(4-methoxyphenyl)hydrazinecarboxamide 
• 1170321-70-6 N-(4-methoxyphenyl)-3-endo-(phenylsulfonyl)-8-azabicyclo[3.2.1]octane-8-carboxamide 
• 2645-37-6 N-(4-methoxyphenyl)piperidine-1-carboxamide 
• 2280-99-1 N-butyl-p-methoxybenzamide 
• 108-95-2 phenol 

Relevant articles and documents

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I

Activation of AMPK emerges as a potential therapeutic approach to metabolic diseases. AdipoRon is claimed to be an adiponectin receptor agonist that activates AMPK through adiponectin receptor 1 (AdipoR1). However, AdipoRon also exhibits moderate inhibition of mitochondrial complex I, leading to increased risk of lactic acidosis. In order to find novel AdipoRon analogues that activate AMPK without inhibition of complex I, 27 analogues of AdipoRon were designed, synthesized and biologically evaluated. As results, benzyloxy arylamide B10 was identified as a potent AMPK activator without inhibition of complex I. B10 dose-dependently improved glucose tolerance in normal mice, and significantly lowered fasting blood glucose level and ameliorated insulin resistance in db/db diabetic mice. More importantly, unlike the pan-AMPK activator MK-8722, B10 did not cause cardiac hypertrophy, probably owing to its selective activation of AMPK in the muscle tissue but not in the heart tissue. Together, B10 represents a novel class of AMPK activators with promising therapeutic potential against metabolic disease.

Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones

Parthenolide is an important sesquiterpene lactone with potent anticancer activities. In order to further improve its biological activity, a series of parthenolide semicarbazone or thiosemicarbazone derivatives was synthesized and evaluated for their anti

2 - Amino pyrimidine compounds and their use (by machine translation)

The invention belongs to the technical field of pharmaceutical chemical synthesis, relates to the general formula (I) indicated by the 2 - amino pyrimidine compounds and their pharmaceutically acceptable salt, solvate or prodrug, their method of preparation and containing pharmaceutical composition of said compound, wherein substituent R1 , R2 , R6 With the meanings given in the specification. The invention also relates to the compounds of the formula I or its pharmaceutical composition for treating and/or preventing malignant blood diseases or other proliferative diseases in the use of the medicament. (by machine translation)