87992-00-5

Basic information

• Product Name: Ethanone, 2-(acetyloxy)-1-(3-chlorophenyl)-
• CAS NO: 87992-00-5
• Molecular Formula: C10H9ClO3
• Molecular Weight: 212.633
• Mol File: 87992-00-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(acetyloxy)-1-(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(acetyloxy)-1-(3-chlorophenyl)-(87992-00-5)
• EPA Substance Registry System: Ethanone, 2-(acetyloxy)-1-(3-chlorophenyl)-(87992-00-5)

Safety Data

• Hazardous Substances Data: 87992-00-5(Hazardous Substances Data)

Upstream product

• 7396-28-3 3-(3-chlorophenyl)prop-2-ynoic acid 
• 349537-55-9 1-acetylamino-1-(3'-chlorophenyl)ethene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 766-83-6 m-chlorophenylacetylene 
• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 

Downstream Products

• 67829-05-4 1-(3-chlorophenyl)-2-hydroxyethanone 
• 80051-04-3 (R)-(-)-1-(3-chlorophenyl)-1,2-ethanediol 
• 152008-72-5 (S)-(+)-1-(3-chlorophenyl)-1,2-ethanediol 
• 115-10-6 Dimethyl ether 
• 79-20-9 acetic acid methyl ester 
• 17264-88-9 sodium 3-chlorobenzoate 
• 2905-65-9 methyl 3-chlorobenzoate 

Relevant articles and documents

Decarboxylative Oxyacyloxylation of Propiolic Acids: Construction of Alkynyl-Containing α-Acyloxy Ketones

Novel decarboxylative oxyacyloxylation of propiolic acids has been developed. This reaction provides an efficient access to alkynyl-containing α-acyloxy ketones from readily available starting materials and exhibits significant functional group tolerance. Furthermore, oxyacyloxylation of terminal alkynes and aliphatic propiolic acids was also developed. A possible reaction mechanism is proposed based on mechanistic studies.

Silver(I)-catalyzed reaction of terminal alkynes with (diacetoxyiodo) benzene: A convenient, efficient and clean preparation of α-acetoxy ketones

Silver(I)-catalyzed reaction of terminal alkynes with (diacetoxyiodo) benzene in wet acetonitrile at room temperature afforded the corresponding α-acetoxy ketones in 55-93% yields. The salient features of this reaction are the effective utilization of PhI

Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists

Leukocyte recruitment of sites of inflammation and tissue injury involves leukocyte rolling along the endothelial wall, followed by firm adherence of the leukocyte, and finally transmigration of the leukocyte across cell junctions into the underlying tissue. The initial rolling step is mediated by the interaction of leukocyte glycoproteins containing active moieties such as sialyl Lewisx (sLex) with P-selectin expressed on endothelial cells. Consequently, inhibition of this interaction by means of a small molecule P-selectin antagonist is an attractive strategy for the treatment of inflammatory diseases such as arthritis. High-throughput screening of the Wyeth chemical library identified the quinoline salicylic acid class of compounds (1) as antagonists of P-selectin, with potency in in vitro and cell-based assays far superior to that of sLex. Through iterative medicinal chemistry, we identified analogues with improved P-selectin activity, decreased inhibition of dihydrooratate dehydrogenase, and acceptable CYP profiles. Lead compound 36 was efficacious in the rat AIA model of rheumatoid arthritis.