88073-05-6

Basic information

• Product Name: 2-(2-oxo-2-phenylethoxy)-1H-isoindole-1,3(2H)-dione
• Synonyms: 1H-isoindole-1,3(2H)-dione, 2-(2-oxo-2-phenylethoxy)-
• CAS NO: 88073-05-6
• Molecular Formula: C₁₆H₁₁NO₄
• Molecular Weight: 281.2628
• Mol File: 88073-05-6.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 463.5°C at 760 mmHg
• Flash Point: 234.1°C
• Density: 1.4g/cm³
• Vapor Pressure: 9.02E-09mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 2-(2-oxo-2-phenylethoxy)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-oxo-2-phenylethoxy)-1H-isoindole-1,3(2H)-dione(88073-05-6)
• EPA Substance Registry System: 2-(2-oxo-2-phenylethoxy)-1H-isoindole-1,3(2H)-dione(88073-05-6)

Safety Data

• Hazardous Substances Data: 88073-05-6(Hazardous Substances Data)

Usage

Molecular structure

Contains a phenylethoxy group attached to an isoindole-1,3(2H)-dione structure.

Type of compound

Heterocyclic compound.

Usage

Commonly used in the field of organic chemistry and pharmaceutical research.

Potential properties

May possess potential biological activities.

Possible applications

Could be used in various medicinal and pharmacological applications.

Additional research needed

Its specific properties and potential uses would need to be further studied and evaluated to fully understand its effects and potential applications.

Upstream product

• 100-42-5 styrene 
• 524-38-9 N-hydroxyphthalimide 
• 70-11-1 α-bromoacetophenone 
• 125349-03-3 2-(2-hydroxy-2-phenylethoxy)-2,3-dihydro-1H-isoindoline-1,3-dione 
• 536-74-3 phenylacetylene 
• 492-38-6 2-phenylacrylic acid 
• 98-81-7 1-bromovinylbenzene 

Downstream Products

• 98-86-2 acetophenone 
• 1021-45-0 phosphoric acid diethyl ester-(1-phenyl-vinyl ester) 
• 136918-14-4 phthalimide 
• 1074-12-0 phenylglyoxal hydrate 

Relevant articles and documents

Cerium(IV) ammonium nitrate: Reagent for the versatile oxidative functionalization of styrenes using N-hydroxyphthalimide

Cerium(IV) ammonium nitrate was found to be a versatile reagent for the oxidative functionalization of styrenes using N-hydroxyphthalimide and iodine affording three different types of products with oxyphthalimide, nitrate and iodide groups. It was shown

Cobalt Catalyst-Controlled Selective Dioxygenation of Styrenes Using N-Hydroxyphthalimide with Molecular Oxygen

A cobalt-catalyzed selective dioxygenation of styrenes with N-hydroxyphthalimide (NHPI) was developed using molecular oxygen as the terminal oxidant. Alcohol and ketone products can be selectively formed from identical substrates by catalyst control. The reaction was applicable to a broad range of styrenes and exhibited good functional group tolerance. It provided a method for preparation of 1,2-diol or α-hydroxyketone derivatives. (Figure presented.).

Electrochemical Difunctionalization of Styrenes via Chemoselective Oxo-Azidation or Oxo-Hydroxyphthalimidation

Atom- and step-economic oxo-azidation and oxo-hydroxyphthalimidation of styrenes have been developed under mild electrolytic conditions, respectively. Various valuable alpha-azido or hydroxyphthalimide aromatic ketones were synthesized efficiently from readily available styrenes, azides, and N-hydroxyphthalimides. Mechanism studies show that two different pathways involved in these two transformations.

Method for preparing 2-(2-oxo-2-phenethoxy) isobenzyl-1, 3-diketone

The invention relates to a method for preparing 2-(2-oxo-2-phenylethoxy) isobenzyl-1, 3-diketone, which comprises the following steps: adding phenylacetylene and N-hydroxyphthalimide into a reactor, introducing oxygen into the reactor, adding 1, 2-dichloroethane, carrying out magnetic stirring, and putting the reactor into an oil bath pot to react; transferring the obtained reaction liquid into aseparating funnel, adding dichloromethane and water for extraction, and collecting a crude product of an organic phase after reduced pressure distillation; and carrying out column chromatography separation on the obtained crude product by adopting a system in which the ratio of ethyl acetate to petroleum ether is 1: 10, so as to obtain a white solid product of 2-(2-oxo-2-phenethoxy) isobenzyl-1, 3-diketone. The synthesis method has the advantages of mild reaction conditions, simple technological process, no participation of catalysts and oxidants and the like.