88239-44-5

Upstream product

• 3724-65-0 2-butenoic acid 
• 75-77-4 chloro-trimethyl-silane 
• 107-93-7 (E)-but-2-enoic acid 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 1825-62-3 ethyl trimethylsilyl ether 
• 623-68-7 crotonic anhydride 
• 4648-54-8 trimethylsilylazide 
• 43112-38-5 3-(trimethylsilyl)-2-oxazolidinone 

Downstream Products

• 87121-06-0 1,1-bis(trimethylsilyloxy)-buta-1,3-diene 
• 55600-70-9 crotonyl bromide 
• 6624-56-2 3-phenylpropyl (E)-2-butenoate 
• 1013916-37-4 2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one 
• 1357518-87-6 (E)-PhSiF[OC(O)CH=CHCH₃]2 
• 1344680-48-3 (E)-PhSiFClOC(O)CH=CHCH₃ 
• 1357518-68-3 (E)-PhSiF₂OC(O)CH=CHCH₃ 
• 150272-55-2 3-phenylpropyl 3-butenoate 
• 75-77-4 chloro-trimethyl-silane 
• 87121-18-4 3-(2,2-Bis-trimethylsilanyloxy-vinyl)-2,2-diphenyl-cyclobutanone 

Relevant academic research and scientific papers

Preparation method of silicon-based ester compound, silicon-based ester compound, electrolyte containing silicon-based ester compound and secondary battery

The invention relates to a preparation method of a silicon-based ester compound, the silicon-based ester compound, an electrolyte containing the silicon-based ester compound and a secondary battery. The preparation method of the silicon-based ester compound comprises the following steps: adding organic alkali and organic acid into a solvent and carrying out reacting to obtain an intermediate, andthen, adding halogenated silane to react with the intermediate to obtain the silicon-based ester compound, wherein the intermediate is ionic liquid. The preparation method provided by the invention can relieve the problems of long reaction time, difficult treatment of byproducts, complex operation caused by step-by-step reaction, high cost, difficult industrial scale-up production and the like inthe existing synthesis method.

Method for Producing Acyloxysilanes, Acyloxysilanes Obtained Thereby, and Use of Same

An object of the invention is to provide a method for efficiently producing an acyloxysilane which is useful as a functional chemical, an acyloxysilane obtained thereby, and the use thereof. The present invention provides: a method for producing an acyloxysilane, including a reaction step of reacting an alkoxysilane with a carboxylic anhydride in the presence of a catalyst, wherein the alkoxysilane is a specified alkoxysilane represented by General Formula (I), the carboxylic anhydride is a specified carboxylic acid represented by General Formula (IIA) or (IIB), the catalyst is an acid catalyst, and an acyloxysilane obtained in the reaction step is a specified acyloxysilane represented by General Formula (IIIA) or (IIIB); and the use of the acyloxysilane as a surface treatment agent or the like.

A PROCESS FOR THE PREPARATION OF PALBOCICLIB

The present invention relates to a process for the preparation of palbociclib utilizing a silyl-protected crotonic acid derivative to produce a silyl-protected 5-(1-methyl-3 carboxy-prop-1-en-1-yl)-2-chloro-piperazine followed by intramolecular cyclization of the compound the piperazine intermediate to produce 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one which is then converted to palbociclib.

CYANOQUINOLINE DERIVATIVES

Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof, wherein R1, R2, R3 and R4 are each as defined in the present application.

CYANOQUINOLINE DERIVATIVES

Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof, wherein R1, R2

A protocol for accessing the β-azidation of α,β-unsaturated carboxylic acids

This contribution reports the preparation and use of a new immobilized catalyst, PS-DABCOF (9), which has been specifically designed to access for the first time the efficient β-azidation of α,β-unsaturated carboxylic acids.

Reagents and synthetic methods. 31. Silylations with N-trimethylsilyl-2-oxazolidinone (TMSO)

Silylation of ketones, alcohols, mercaptans, and carboxylic acids with N-trimethylsilyl-2-oxazolidinone (TMSO) and triflic acid as catalyst has been described from synthetic and mechanistic points of view.

Halogenated Ketenes. 37. The Synthesis of Pyranones Utilizing the (4 + 2) Cycloaddition of Ketenes and Siloxy Dienes

The reaction of diphenyl-, dichloro-, and chloroketenes with several siloxy dienes results in (4 + 2) and/or (2 + 2) cycloaddition products depending primarily on substitution in the diene.The (4 + 2) cycloaddition products are easily hydrolyzed to pyranones.These results are discussed in terms of a dipolar intermediate.