109921-38-2

Upstream product

• 109921-36-0 5-chloro-2-<2-<(2-hydroxyethyl)(phenylmethyl)amino>ethyl>-7-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 
• 111-41-1 2-(2-Aminoethylamino)ethanol 
• 6770-15-6 1,4-dichloro-5-hydroxy-9,10-anthracenedione 
• 100-39-0 benzyl bromide 
• 67-63-0 isopropyl alcohol 
• 88303-56-4 1,4-dichloro-5-(phenylmethoxy)-9,10-anthracenedione 

Downstream Products

• 88303-60-0 7-hydroxy-2-{2-[(2-hydroxyethyl)amino]ethyl}-5-({2-[(2-hydroxyethyl)amino]ethyl}amino)anthra(1,9-cd)pyrazol-6(2H)-one 
• 88303-61-1 losoxantrone 

Relevant academic research and scientific papers

Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride

Improved processes for the synthesis of bulk quantities of the anthrapyrazole clinical agents CI-937, CI-941, and piroxantrone hydrochloride are reported. Reported also are detailed analytical and spectroscopic data for these agents and intermediates of t

Process for preparing substituted anthra[1,9-cd]pyrazol-6(2H)-ones

An improved process for producing anthra[1,9-cd]-pyrazol-6(2H)-ones from 1,4-dichloro-5,8-disubstituted 9,10-anthracenediones. The process produces higher yields by using a new combination of protecting groups on the compounds which allows for easier and cleaner chromatographic resolution. The compounds produced have antibacterial, antifungal, antileukemic, and antitumor activity.