88406-57-9Relevant academic research and scientific papers
Oxidative Cyclization Approach to Benzimidazole Libraries
Arnold, Eric P.,Mondal, Prolay K.,Schmitt, Daniel C.
supporting information, p. 1 - 5 (2020/02/20)
An efficient approach to the parallel synthesis of benzimidazoles from anilines is described. Library approaches to vary the N1 and C2 vectors of benzimidazoles are well established; however, C4-C7 variation has traditionally relied on 1,2-dianiline build
Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists
Kulkarni, Santosh S.,Newman, Amy Hauck
, p. 2987 - 2991 (2008/02/07)
Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.
Reaction of β-Aminocrotonamide with N-Acylated Amino Acid Esters to give 2-Acylaminoalkyl-6-methylpirimidin-4(3H)-ones and Their Ring Closure with Polyphosphoric Acid (PPA)
Katagiri, Nobuya,Koshihara, Akemi,Atsuumi, Shugo,Kato, Tetsuzo
, p. 2288 - 2295 (2007/10/02)
Reaction of β-aminocrotonamide with N-acylated amino acid esters in the presence of sodium methoxide gave 2-acylaminoalkyl-6-methylpyrimidin-4(3H)-ones, some of wich, on treatment with polyphosphoric acid (PPA), were transformed into imidazopyrimidines and imidazopyridines.
