88460-63-3Relevant academic research and scientific papers
Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation - amination - Michael addition cascade
Grigg, Ronald,Gai, Xinjie,Khamnaen, Tossapol,Rajviroongit, Shuleewan,Sridharan, Visuvanathar,Zhang, Lixin,Collard, Simon,Keep, Ann
, p. 990 - 1005 (2005)
We herein describe a novel palladium catalysed three-component cascade process involving carbonylation of an aryl iodide to generate an acyl palladium(II) species that is intercepted by a primary aliphatic or aromatic amine, amide, or sulfonamide followed
Ru(II)-Catalyzed Oxidative Olefination of Benzamides: Switchable Aza-Michael and Aza-Wacker Reaction for Synthesis of Isoindolinones
Kumar, Manoj,Verma, Akhilesh K.,Verma, Shalini
, (2020/06/25)
Selective tandem oxidative C-H olefination-aza-Michael/aza-Wacker reaction of N-arylbenzamides is achieved by fine-tuning between base and additive to access valuable 3-oxoisoindolinyls and 3-oxoisoindolinylidenes, respectively. Careful optimization and c
Unified approach to isoindolinones and THIQs via lewis acid catalyzed domino mukaiyama-mannich Lactamization/Alkylations: Application in the synthesis of (±)-homolaudanosine
Dhanasekaran, Sivasankaran,Kayet, Anirban,Suneja, Arun,Bisai, Vishnumaya,Singh, Vinod K.
supporting information, p. 2780 - 2783 (2015/06/16)
A novel and efficient synthesis of a variety of isoindolinones and tetrahydroisoquinolines via a Lewis acid catalyzed domino Mukaiyama-Mannich lactamization/alkylation is achieved. This transformation comprises a sequential formation of three new bonds through a one-pot, three-component procedure to afford product in moderate to high yields. A concise synthesis of (±)-homolaudanosine (2b) has been achieved using this method.
Palladium mediated synthesis of isoindolinones and isoquinolinones
Wahab Khan,Masud Reza
, p. 11204 - 11210 (2007/10/03)
The palladium-catalyzed reactions of 2-iodo-N-substituted benzamides 5-10 with acrylic esters 11-14 led to N-substituted-3-alkylisoindolinone esters 15-22 in good yields. The esters of isoindolinones 15-22 underwent hydrolysis reactions yielding the N-aryl-1,2,3,4-tetrahydro-1-oxoisoquinoline-3-carboxylic acid 26-31 in good yields.
Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process
Gaj, Xinjie,Grigg, Ronald,Khamnaen, Tossapol,Rajviroongit, Shuleewan,Sridharan, Visuvanathar,Zhang, Lixin,Collard, Simon,Keep, Ann
, p. 7441 - 7444 (2007/10/03)
A novel palladium-catalysed three component cascade process is described involving carbonylation of an aryl iodide to generate an acyl palladium species which is intercepted by a primary aliphatic/aromatic amine, amide or sulfonamide followed by intramolecular Michael addition to afford 3-substituted isoindolin-1-ones in good yield.
Condensed pyrrolinone derivatives, their production and use
-
, (2008/06/13)
The compound of the formula STR1 wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH CH--CH CH--, --S--(CH 2) l --S--(l is an integer of 1 to 3), --N CH--CH N-- o
