89240-67-5Relevant academic research and scientific papers
Apomorphinans from Isoquinolines: Grewe Cyclization of 1-(2-Hydroxybenzyl)-N-methyloctahydroisoquinoline and its O-Methyl Ether
Schmidhammer, Helmut,Brossi, Arnold,Flippen-Anderson, Judith L.,Gilardi, Richard
, p. 2437 - 2442 (1983)
Wolff-Kishner reduction of the optically active ketomorphinan 5 afforded the optically active morphinan 6 differing chromatographically and spectroscopically from the material obtained in a Grewe-cyclization of the isoquinoline 1.A single crystal X-ray analysis of a hydrobromide salt of a phenolic amine obtained from 1 and 2 with refluxing hydrobromic acid showed this compound to be the N-methylapomorphinan 4.
