895537-30-1

Basic information

• Product Name: Benzenemethanamine, N-(4-chlorophenyl)-a-methyl-, (aR)-
• Synonyms: Benzenemethanamine, N-(4-chlorophenyl)-a-methyl-, (aR)-
• CAS NO: 895537-30-1
• Molecular Formula: C14H14ClN
• Molecular Weight: 231.725
• Mol File: 895537-30-1.mol
• Article Data: 63

Chemical Properties

• Boiling Point: 354°C at 760 mmHg
• Flash Point: 167.9°C
• Appearance: /
• Density: 1.165g/cm³
• Vapor Pressure: 3.45E-05mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: Benzenemethanamine, N-(4-chlorophenyl)-a-methyl-, (aR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-(4-chlorophenyl)-a-methyl-, (aR)-(895537-30-1)
• EPA Substance Registry System: Benzenemethanamine, N-(4-chlorophenyl)-a-methyl-, (aR)-(895537-30-1)

Safety Data

• Hazardous Substances Data: 895537-30-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H14ClN/c1-11(12-5-3-2-4-6-12)16-14-9-7-13(15)8-10-14/h2-11,16H,1H3/t11-/m1/s1

Upstream product

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Relevant articles and documents

Iodine-mediated 1,2-aryl migration of primary benzhydryl amines

An iodine-mediated 1,2-aryl migration reaction of primary benzhydryl amines under transition metal-free conditions has been achieved. The crude imines generated by this rearrangement reaction can be directly transformed into various aromatic secondary ami

Chiral Arylated Amines via C?N Coupling of Chiral Amines with Aryl Bromides Promoted by Light

The Buchwald-Hartwig C-N coupling reaction has found widespread applications in organic synthesis. Over the past two decades or so, many improved catalysts have been introduced, allowing various amines and aryl electrophiles to be readily used nowadays. However, there lacks a protocol that could be used to couple a wide range of chiral amines and aryl halides, without erosion of the enantiomeric excess (ee). Reported in this article is a method based on molecular Ni catalysis driven by light, which enables stereoretentive C-N coupling of optically active amines, amino alcohols, and amino acid esters with aryl bromides, with no need for any external photosensitizer. The method is effective for a wide variety of coupling partners, including those bearing functional groups sensitive to bases and nucleophiles, thus providing a viable alternative to accessing synthetically important chiral N-aryl amines, amino alcohols, and amino acids esters. Its viability is demonstrated by 92 examples with up to 99 % ee.

Iron-catalyzed reductive coupling of nitroarenes with olefins: Intermediate of iron-nitroso complex

Using a single half-sandwich iron(II) compound, CpFe(1,2-Ph2PC6H4S)(NCMe) (Cp- = C5Me5-, 1) as a catalyst, reductive coupling of nitroarenes with olefins has been achieved by a well-defined iron(II)/(EtO)3SiH system. Through either inter- or intramolecular reductive coupling, various branched amines and indole derivatives have been directly synthesized in one-pot. Mechanistic studies showed that the catalysis is initiated by activation of nitroarenes by the iron(II) catalyst with silane, generating iron-nitrosoarene intermediate for the C-N bond coupling.